中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (7): 434-438.doi: 10.12144/zgmfskin202207434

• 论著 • 上一篇    下一篇

552例男性HPV感染者基因型分布及临床特征分析

肖海璐1,卢彬1,刘利华2,谭兴友1,牛李莉1,鲁楠1,姚树兰1,刘香1   

  1. 1济宁医学院附属医院皮肤科，山东济宁，272000;2济宁医学院附属医院检验科，山东济宁，272000
  • 出版日期:2022-07-15 发布日期:2022-05-17

Analysis of HPV genotypes and clinical features in 552 male patients

XIAO Hailu1, LU Bin1, LIU Lihua2, TAN Xingyou1, NIU Lili1, LU Nan1, YAO Shulan1, LIU Xiang1   

  1. 1 Department of Dermatology, Affiliated Hospital of Jining Medical University, Jining 272000, China; 2 Department of Medical Laboratory, Affiliated Hospital of Jining Medical University, Jining 272000, China
  • Online:2022-07-15 Published:2022-05-17

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摘要： 目的：分析人乳头瘤病毒在男性感染者中的基因型分布及临床特征。方法：回顾性分析我院2017年1月至2021年7月HPV基因分型检测阳性的男性患者临床资料。结果：共分析552例男性HPV感染者，其中HPV6、11、16和51是最常见的感染亚型，占比分别为35.51%、23.73%、16.49%、10.14%。HPV高危亚型占63.95%(单纯高危型感染占比+高低危混合型感染占比)。单一感染占比为56.88%，多重感染（含二重感染）占比为43.12%。与临床联系方面，552例男性HPV感染者中，335例（60.69%）表现为尖锐湿疣，以HPV6、11型感染为主；鲍温样丘疹病7例，以HPV16型感染为主；210例（38.04%）为HPV亚临床感染者，以HPV16、52、58、51型感染为主。结论：本研究中，HPV6、11、16和51是最常见HPV感染亚型，高危HPV感染和单一感染占比高。亚临床感染占比较高，且以高危型HPV感染为主，值得临床警惕。

关键词: 人乳头瘤病毒, 男性, 亚临床感染

Abstract: Objective: To analyze the genotype distribution and clinical characteristics of human papillomavirus (HPV) in male patients. Methods: The data of the patients with HPV positivity from January 2017 to July 2021 in our hospital were collected and analyzed retrospectively. Results: 552 patients and samples were collected. Of 552 samples, HPV6, 11, 16 and 51 were the most common subtypes, with proportions of 35.51%, 23.73%, 16.49% and 10.14% respectively. The proportion of high-risk HPV subtypes accounted for 63.95% (simple high-risk infection+polyinfection). In different types of infection, single infection proportion was 56.88%, multiple infection proportion was 43.12%. In the clinical aspect, of 552 cases, 335 (60.69%) manifested as condyloma acuminatum and the most common subtypes were HPV6 and 11, 7 manifested as bowenoid papulosis and the most common subtypes was HPV16, 210（38.04%） were asymptomatic carriers and the most common subtypes were HPV16,52,58 and 51.  Conclusion: HPV6, 11, 16 and 51 are the most common subtypes of HPV in this study, and the  high-risk HPV proportion and single infection proportion are both high. The propotion of asymptomatic carriers is high and high-risk HPV infection is the main type, which should be noted.

Key words: human papillomavirus, men, subclinical infection