中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (2): 138-141.doi: 10.12144/zgmfskin202302138

• 综述 • 上一篇    下一篇

JAK抑制剂治疗儿童斑秃的研究进展

张兰1,史冬梅2,王玮2   

  1. 1济宁医学院，山东济宁，272067;
    2济宁市第一人民医院皮肤科，山东济宁，272000
  • 出版日期:2023-02-15 发布日期:2022-12-28

Update of JAK inhibitors in the treatment of alopecia areata in children

ZHANG Lan1, SHI Dongmei2, WANG Wei2   

  1. 1 Jining Medical College, Jining 273500, China;
    2 Department of Dermatology, Jining first people's Hospital, Jining 272067, China
  • Online:2023-02-15 Published:2022-12-28

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摘要： 斑秃（AA）是一种常见的非瘢痕性脱发，儿童斑秃预后不佳、病情易反复，可严重影响患者及家长的心理健康和生活质量。近年来，人们逐渐发现酪氨酸蛋白激酶(JAK)/信号转导与转录激活因子(STAT)信号通路在斑秃的发病机制中起着重要作用。目前已有多篇病例报告和小型临床试验报道JAK抑制剂治疗儿童斑秃的有效性及安全性，因此JAK抑制剂对于儿童中重度斑秃的治疗可能会成为一种新的选择。

关键词: JAK抑制剂, 斑秃, 儿童

Abstract: alopecia areata (AA) is a common non scar hair loss. The prognosis of AA in children is poor and the condition is easy to repeat, which can seriously affect the mental health and quality of life of patients and parents. In recent years, it has been gradually found that tyrosine protein kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway plays an important role in the pathogenesis of AA. At present, many case reports and small clinical trials have reported the efficacy and safety of JAK inhibitors in the treatment of childhood alopecia areata. Therefore, JAK inhibitors may become a new choice for the treatment of moderate and severe AA in children.

Key words: JAK inhibitors, alopecia areata, children