中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (4): 236-241.doi: 10.12144/zgmfskin202304236

• 论著 • 上一篇    下一篇

伊曲康唑口服液治疗婴儿脓癣五例并文献复习

张牧秋1,2,庄凯文1,冉昕1,周宜可1,2,Sushmita Pradhan1,冉玉平1   

  1. 1四川大学华西医院皮肤性病科，四川成都，610041；
    2四川大学华西临床医学院, 四川成都，610041
  • 出版日期:2023-04-15 发布日期:2023-03-27

Five cases of infant kerion celsi successfully treated with oral itraconazole solution and literature review

ZHANG Muqiu1,2, ZHUANG Kaiwen1, RAN Xin1, ZHOU Yike1,2, Sushmita Pradhan1, RAN Yuping1   

  1. 1 Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu 610041, China;
    2 West China Hospital, West China School Medicine, Sichuan University, Chengdu 610041, China
  • Online:2023-04-15 Published:2023-03-27

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摘要： 本文报道5例经由伊曲康唑口服液治疗成功的婴儿脓癣并复习相关文献。5例患儿，年龄2~12个月，临床表现为头皮红斑、鳞屑、脓肿、脱发，诊断依据为皮肤镜下病发特点及取病发行钙荧光白染色后荧光显微镜检确认真菌孢子和（或）菌丝累及毛干、头皮。5例经伊曲康唑口服液5 mg/kg·d治疗后均痊愈，疗程3~12周。1例治疗过程中出现可逆性轻度短暂腹泻，未停药逐渐缓解。通过文献检索到7例伊曲康唑治疗婴儿头癣的报道，对病例特点及疗效进行分析总结。伊曲康唑口服液治疗婴儿头癣方便、安全、有效且耐受性良好。

关键词: 婴儿, 头癣, 脓癣, 皮肤镜, 钙荧光白染色荧光显微镜检, 伊曲康唑口服液

Abstract: We report 5 cases of infant kerion celsi treated with itraconazole oral solution and review the related literature. The 5 cases were aged from 2 to 12 months, clinical manifestations included scalp erythema, scales, abscess and alopecia. The diagnosis was based on the dermascopy characteristics of the damaged hair, the fungal spores and/or hyphae confirmend under the fluorescence microscope after the calcium fluorescence white staining of the diseased hairs. The 5 cases were all cured with itraconazole solution at a dosage of 5 mg/kg·d, and the treatment courses varied from 3 to 12 weeks. Only one patient had mild transient diarrhea during the treatment process, and gradually relieved without medication withdrawal. The characteristics and efficacy of itraconazole in treating infantile tinea capitis from the 7 cases reported in the literature were analyzed. The conclusion of itraconazole oral solution is convenient, safe, effective and well tolerated in treating infantile tinea capitis.

Key words: infant, tinea capitis, kerion celsi, dermoscopy, calcium fluorescent microscopy, itraconazole oral solution