甲扁平苔藓,托法替布," /> 甲扁平苔藓,托法替布,"/> nail lichen planus, tofacitinib,"/> 托法替布治疗甲扁平苔藓一例

中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (8): 576-577.doi: 10.12144/zgmfskin202408576

• 病例报告 • 上一篇    下一篇

托法替布治疗甲扁平苔藓一例

薛晓彤1,2,赵晴1,2,曹珊1,2,刘永霞1,2,周桂芝1,2,张福仁1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2024-08-15 发布日期:2024-07-29

Nail lichen planus treated with tofacitinib: a case report

XUE Xiaotong1,2, ZHAO Qing1,2, CAO Shan1,2, LIU Yongxia1,2, ZHOU Guizhi1,2, ZHANG Furen1,2   

  1. 1 Hospital for Skin Diseases, Shandong First Medical University, Jinan 250022, China；2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2024-08-15 Published:2024-07-29

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摘要： 甲扁平苔藓发病机制不清，尚缺乏明确的用药指导方案，既往报道糖皮质激素、阿维A、免疫抑制剂（如甲氨蝶呤、环孢素、吗替麦考酚酯）、生物制剂（如依那西普）、氨苯砜等对治疗甲扁平苔藓有一定疗效，但大部分只能缓解。近期有研究发现JAK/STAT信号通路在甲扁平苔藓致病中可能发挥重要作用,且已有4例JAK抑制剂治疗相关报道。本文报道1例使用JAK抑制剂枸橼酸托法替布缓释片治疗甲扁平苔藓的患者，4个月后部分甲损害改善，见新甲生长，目前随访中。

关键词: 甲扁平苔藓')">">甲扁平苔藓, 托法替布

Abstract: The pathogenesis of nail lichen planus is unclear, and lack of clear drug guidance. It has been reported that glucocorticoids, avitamin A, immunosuppressants (such as methotrexate, cyclosporine, morpheolate), biologics (such as etanercept), and sulfoxone have certain effects on the treatment of lichenus planus, but most of them can only alleviate. Recent studies have found that the JAK/STAT signaling pathway may play an important role in the pathogenesis of nail lichen planus, and 4 cases of JAK inhibitor treatment have been reported. This paper reports a case which the JAK inhibitor tofacitinib citrate sustained release tablets were used to treat onychlichen planus. After 4 months, partial onychia damage was improved and new nail growth was observed.

Key words: nail lichen planus')">">nail lichen planus, tofacitinib