中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (5): 355-357.doi: 10.12144/zgmfskin202505355

• 病例报告 • 上一篇    下一篇

奥马珠单抗成功治疗嗜酸性脓疱性毛囊炎一例

王娜1,2*,于长平1,2*,王伟伟1,2,刘永霞1,2,杨青1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022 *共同第一作者
  • 出版日期:2025-05-15 发布日期:2025-05-15

Successful treatment of a eosinophilic pustular folliculitis patient with omalizumab

WANG Na1,2*, YU Changping1,2*, WANG Weiwei1,2, LIU Yongxia1,2, YANG Qing1,2   

  1. 1 Dermatology Hospital of Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China *Co-first author
  • Online:2025-05-15 Published:2025-05-15

PDF (PC)

16

摘要： 嗜酸性脓疱性毛囊炎（eosinophilic pustular folliculitis,EPF）以面部、躯干和四肢反复出现的无菌性丘疹、脓疱为特征，目前没有有效的治疗方法。本文报道奥马珠单抗成功治疗EPF一例。患者，女，40岁，确诊EPF后，给予局部外用0.1%他克莫司软膏2周，无效。该患者复发频率高且血清IgE水平较高，获得患者知情同意后，予奥马珠单抗150 mg每月1次，2个月后，皮损完全消失，3个月后停药，之后随访一年，患者无复发。

关键词: 嗜酸性, 脓疱性毛囊炎, 奥马珠单抗

Abstract: Eosinophilic pustular folliculitis (EPF) characterized by recurrent sterile papulopustules on the trunk, face, and extremities. We reported a case of EPF treated with omalizumab in this paper. The patient was a 40-year-old female. After being diagnosed with EPF, she was given topical 0.1% tacrolimus ointment for 2 weeks, but it was ineffective. Based on the high recurrence rate and high serum IgE level, omalizumab was used for treatment at a dose of 150 mg per month after obtaining the patient's consent. The skin lesions completely disappeared after 2 months of treatment, and the drug was discontinued after 3 months of treatment. After that, the patient was followed up for one year, and there was no recurrence.

Key words: eosinophilic, pustular folliculitis, omalizumab