中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (6): 461-465.doi: 10.12144/zgmfskin202506461

• 综述 • 上一篇    下一篇

骨膜蛋白在瘢痕疙瘩形成机制中的研究进展

黄储涵1,2,4,何治宏1,3,4,钟施怡1,2,4,王之涵1,2,4,陈辉松1,2,4,杨顶权2,4,刘青武2,4   

  1. 1北京中医药大学，北京，100029； 2中日友好医院皮肤科，北京，100029； 3北京中医药大学东方医院皮肤科，北京，100078； 4国家中西医结合医学中心，北京，100029
  • 出版日期:2025-06-15 发布日期:2025-05-23

Update of periostin in the mechanism of keloid formation

HUANG Chuhan1,2,4, HE Zhihong1,3,4, ZHONG Shiyi1,2,4, WANG Zhihan1,2,4, CHEN Huisong1,2,4, YANG Dingquan2,4, LIU Qingwu2,4   

  1. 1 Beijing University of Traditional Chinese Medicine, Beijing 100029, China; 2 Department of Dermatology, China-Japan Friendship Hospital, Beijing 100029, China; 3 Department of Dermatology, Dongfang Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100078, China; 4 National Center for Integrated Traditional Chinese and Western Medicine, Beijing 100029, China
  • Online:2025-06-15 Published:2025-05-23

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摘要： 骨膜蛋白是一种细胞外基质蛋白，可通过各种整合素与细胞相互作用，参与多种促纤维化过程，在增殖和重塑阶段伤口愈合过程及瘢痕异常增生中起重要推动作用。本文就骨膜蛋白基本特征和功能以及与瘢痕疙瘩形成的关系进行综述。

关键词: 骨膜蛋白, 瘢痕疙瘩, 机制

Abstract: Periostin is an extracellular matrix protein that interacts with cells through various integrins and participates in a variety of pro-fibrotic processes, playing an important role in the normal wound healing process and abnormal scar hyperplasia at the stage of proliferation and remodeling. This paper reviews the basic features and functions of periostin and its relationship with keloid formation.

Key words: periostin, keloids, formation mechanism