中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (6): 466-470.doi: 10.12144/zgmfskin202506466

• 综述 • 上一篇    

脐带间充质干细胞促进皮肤再生研究进展

章哲1,刘明月1,白朝2   

  1. 1天津中医药大学，天津，301617；2天津市中医药研究院附属医院，天津，300120
  • 出版日期:2025-06-15 发布日期:2025-05-23

Update of umbilical cord mesenchymal stem cells in promoting skin regeneration

ZHANG Zhe1, LIU Mingyue1, BAI Zhao2   

  1. 1 Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; 2 Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China
  • Online:2025-06-15 Published:2025-05-23

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摘要： 脐带间充质干细胞（UCMSCs）因其多能分化性、免疫调节能力和丰富的外泌体分泌，在皮肤再生和伤口愈合领域展现出巨大潜力。UCMSCs通过分泌外泌体参与伤口愈合的各个阶段，包括止血、炎症、增殖和重塑。UCMSCs已成功用于急性创伤、烧伤、慢性伤口及皮肤老化的治疗，表现出良好的疗效和安全性。本文就UCMSCs促进皮肤愈合机制以及在临床中的应用进行阐述。

关键词: 间充质干细胞, 皮肤再生, 创伤愈合

Abstract: Umbilical cord mesenchymal stem cells (UCMSCs) have great potential in the field of skin regeneration and wound healing due to their multipotent differentiation capacity, immune regulatory ability, and abundant secretion of exosomes. UCMSCs participate in all stages of wound healing, including hemostasis, inflammation, proliferation, and remodeling, through the secretion of exosomes. UCMSCs have been successfully applied in the treatment of acute trauma, burns, chronic wounds, and skin aging, showing good efficacy and safety. This paper elaborates on the mechanisms of UCMSCs promoting skin healing and their applications in clinical practice.

Key words: mesenchymal stem cells, skin regeneration, wound healing