中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (5): 389-392.doi: 10.12144/zgmfskin202505389

• 综述 • 上一篇    

来源于间充质干细胞的外泌体在改善皮肤光老化机制中的研究进展

王颖,闫言   

  1. 中国医学科学院，北京协和医学院，整形外科医院皮肤科，北京，100144
  • 出版日期:2025-05-15 发布日期:2025-05-15

Research progress on the mechanism of exosomes derived from mesenchymal stem cells in improving skin photoaging

WANG Ying, YAN Yan   

  1. Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, China
  • Online:2025-05-15 Published:2025-05-15

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摘要： 近年来，间充质干细胞来源的外泌体在改善皮肤光老化研究中备受关注,但不同间充质干细胞来源的外泌体在改善皮肤光老化上机制上的差异却少有探讨。本文综述了脂肪组织间充质干细胞、人脐带间充质干细胞、骨髓间充质干细胞三种类型的间充质干细胞以及人类诱导多能干细胞等其他干细胞来源的外泌体在改善皮肤光老化机制上的研究进展，为开展不同干细胞来源的外泌体改善皮肤光老化提供理论依据。

关键词: 间充质干细胞, 外泌体, 皮肤光老化, 紫外线

Abstract: Mesenchymal stem cell derived exosomes, as a non-cellular therapeutic agent, have attracted much attention in the research on treatment and improvement of skin photoaging in recent years. However, whether there are mechanistic differences in improving skin photoaging between exosomes from different sources of mesenchymal stem cells has rarely been explored. This paper reviews the research progress of exosomes from three types of mesenchymal stem cells, namely adipose tissue mesenchymal stem cells, human umbilical cord mesenchymal stem cells, and bone marrow mesenchymal stem cells, as well as other stem cell sources such as human induced pluripotent stem cells, in the mechanism of improving the mechanisms of skin photoaging, providing a theoretical basis for the use of exosomes from different stem cell sources to improve skin photoaging.

Key words: mesenchymal stem cells, exosomes, skin photoaging, ultraviolet