中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (10): 676-678.doi: 10.12144/zgmfskin202110676

• 综述 • 上一篇    下一篇

外泌体在感染性疾病免疫调控中的作用

谢嘉豪1,陈佳玲1,黄峥1,邹锐涛1,蔡桂月1,陈嵘祎1,王柳苑2   

  1. 1 广东医科大学&广东医科大学附属医院，湛江，524000；2南方医科大学皮肤病医院，广州，510095
  • 出版日期:2021-10-25 发布日期:2021-09-01
  • 通讯作者: 王柳苑，E-mail：qqmaomaochong@163.com；陈嵘祎，E-mail：rongyichen@163.com

The role of exosomes in the immune regulation of infectious diseases

XIE Jiahao1, CHEN Jialing1, HUANG Zheng1, ZOU Ruitao1, CAI Guiyue1, CHEN Rongyi1, WANG Liuyuan2   

  1. 1 Guangdong Medical University & Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China; 2 Dermatology Hospital, Southern Medical University, Guangzhou 510095, China
  • Online:2021-10-25 Published:2021-09-01
  • Contact: WANG Liuyuan, E-mail: qqmaomaochong@163.com；CHEN Rongyi, E-mail: rongyichen@163.com

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摘要： 外泌体是基于细胞内膜的双层囊泡小体，具有与生物学和病理学相关的各种组成成分。外泌体存在于多种体液当中，其内含有多种DNA和mRNA片段、非编码RNA分子、蛋白质和脂质等多种生物分子，在细胞信息传递中起重要作用，参与细胞凋亡、血管生成、免疫调节、肿瘤迁移等多种病理生理过程。本文综述了外泌体在感染性疾病免疫调节中的作用。

关键词: 外泌体, 性传播疾病, 感染, 免疫调节, microRNA

Abstract: Exosomes are double-layered vesicles based on the inner cell membrane, with various components related to biology and pathology. Exosomes exist in a variety of body fluids, containing a variety of DNA and mRNA fragments, non-coding RNA molecules, proteins and lipids and other biological molecules. They play an important role in cell information transmission and participate in a variety of pathophysiological processes, such as apoptosis, angiogenesis, immune regulation, tumor migration, etc. The role of exosomes in the immune regulation of infectious diseases is reviewed in this article.

Key words: exosomes, sexually transmitted diseases, infection, immunomodulatory, microRNA