中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (8): 545-548.doi: 10.12144/zgmfskin202508545

• 新发与再发感染性皮肤病 • 上一篇    下一篇

鱼刺扎伤后雷金斯堡预研菌感染一例

张雪英,曹阳,欧内玉   

  1. 单县中心医院,山东单县,274300
  • 出版日期:2025-08-15 发布日期:2025-07-31

Yokenella regensburgei infection after fishbone pricking: a case report

ZHANG Xueying, CAO Yang, OU Neiyu   

  1. Shanxian Central Hospital, Shanxian 274300, China
  • Online:2025-08-15 Published:2025-07-31

摘要: 雷金斯堡预研菌是罕见的机会致病菌,主要感染免疫功能低下的个体。本文报道一例鱼刺扎伤后发生局部雷金斯堡预研菌感染的免疫功能正常者。患者,男,60岁,左手中指鱼刺扎伤50天后出现红肿、痛,外用红霉素软膏3天后症状加重,结合细菌培养、形态学诊断、生化诊断、质谱诊断、16S rRNA测序及全基因测序,最终诊断为雷金斯堡预研菌感染。给予盐酸多西环素口服及夫西地酸乳膏外用等治疗,32天后痊愈,随访半年无复发。

关键词: 雷金斯堡预研菌, 皮肤感染, 海分枝杆菌

Abstract: Yokenella regensburgei is a rare opportunistic pathogen that primarily infects immunocompromised individuals. This paper presents a patient with normal immune function who suffered localized Yokenella regensburgei infection after a fish bone injury. A 60-year-old male presented with redness, swelling and pain for 50 days after a fish bone injury in the middle finger of the left hand, which worsened after 3 days of topical erythromycin ointment. According to bacterial culture, morphological identification, biochemical identification, mass spectrometry identification, 16S rRNA sequencing and whole gene sequencing, the patient was finally identified as Yokenella regensburgei infection. The patient was treated with oral doxycycline hydrochloride and topical fusidic acid cream, and recovered 32 days later. No recurrence was observed during the follow-up of half a year.

Key words: Yokenella regensburgei, skin infection, Mycobacterium marinum