中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (8): 606-608.doi: 10.12144/zgmfskin202508606

• 病例报告 • 上一篇    下一篇

小汗腺螺旋腺癌一例

徐作佼,孙怡,房现刚,王辉,王振华   

  1. 潍坊市人民医院皮肤科，山东潍坊，261000
  • 出版日期:2025-08-15 发布日期:2025-08-01

Eccrine spiradenocarcinoma: a case report

XU Zuojiao, SUN Yi, FANG Xiangang, WANG Hui, WANG Zhenhua   

  1. Department of Dermatology, Weifang People's Hospital, Weifang 261000, China
  • Online:2025-08-15 Published:2025-08-01

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摘要： 小汗腺螺旋腺癌是一种十分罕见的皮肤恶性肿瘤，临床表现不典型，本文报道一例。患者，女，62岁。头皮红色结节10年，破溃、出血、疼痛2年。组织病理示肿瘤呈多叶状分布，由单一的基底样细胞组成，细胞轻度不典型性，病理性分裂像常见，部分区域可见螺旋腺瘤成分，呈特征性花瓣样结构。免疫组化：广谱CK（＋）、P63（＋）、CD5/6（＋）、导管EMA(+)和CEA(+)，CK7（少许＋）、Ki-67指数（局部15％）。诊断为小汗腺螺旋腺癌。给予病损扩大切除术，术后恢复良好，随访30个月未见复发或转移。

关键词: 小汗腺螺旋腺癌, 皮肤肿瘤

Abstract: Eccrine spiral adenocarcinoma is a very rare cutaneous malignant tumor with atypical clinical manifestations. A case of eccrine spiradenocarcinoma was reported. The patient was a 62-year-old female who presented with red nodules on the scalp for 10 years, ulceration, bleeding, and pain for 2 years. Histopathological examination showed the tumor was composed of a single basal-like cell pattern in a multilobulated pattern, with mildly atypical cells. Pathological mitotic figures were common, and spiral adenoma elements were seen in some areas. Immunohistochemical staining found extensive CK (+), P63 (+), CD5/6 (+), positive EMA(+) and CEA(+), CK7 (slightly +), Ki-67 index (local 15%). The diagnosis of eccrine spiradenocarcinoma was made. After extensive resection of the lesion, the patient recovered well, and no recurrence or metastasis was found during a follow-up of 30 months.

Key words: eccrine spiradenocarcinoma, skin neoplasm