中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (3): 178-184.doi: 10.12144/zgmfskin202603178

• 临床研究 • 上一篇    下一篇

大疱型坏疽性脓皮病合并多发性骨髓瘤一例并文献复习

林昭萍1,2,3*,朱梓墨1,3,4*,田蔚蔚1,3,黄秋凤5,吴瑕1,3,于波1,2,3,4,沈长兵1,2,3   

  1. 1北京大学深圳医院皮肤性病科，广东深圳，518036；2汕头大学医学院北大深圳临床学院，广东深圳，518036；3深圳北京大学-香港科技大学医学中心皮肤病研究所，广东深圳，518036；4深圳大学医学部，广东深圳，518055；5深圳市罗湖区人民医院皮肤科，广东深圳，518035 *共同第一作者
  • 出版日期:2026-03-15 发布日期:2026-03-09

Bullous pyoderma gangrenosum in a patient with multiple myeloma: a case report and literature review

LIN Zhaoping1,2,3*, ZHU Zimo1,3,4*, TIAN Weiwei1,3, HUANG Qiufeng5, WU Xia1,3, YU Bo1,2,3,4, SHEN Changbing1,2,3   

  1. 1 Department of Dermatology and Venereology, Peking University Shenzhen Hospital, Shenzhen 518036, China; 2 PKU-Shenzhen Clinical Institute of Shantou University Medical College, Shenzhen 518036, China; 3 Institute of Dermatology, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen 518036, China; 4 Shenzhen University Medical School, Shenzhen 518055, China; 5 Department of Dermatology, Shenzhen Luohu People's Hospital, Shenzhen 518035, China *Co-first authors
  • Online:2026-03-15 Published:2026-03-09

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摘要： 多发性骨髓瘤（multiple myeloma, MM）合并坏疽性脓皮病（pyoderma gangrenosum, PG）少见，其内在关联尚未明确。本文报道来那度胺治疗MM期间并发大疱型PG 1例。有文献报道MM患者合并PG与来那度胺有关，本例患者停用来那度胺后，经甲泼尼龙、环孢素A及多西环素治疗后皮损逐渐愈合，11个月后皮损完全愈合。但患者出院随访6个月后MM复发，血液内科予VPD(泊马度胺+硼替佐米+地塞米松)等方案治疗。此外，本文对国内外报道的14篇PG合并MM文献进行复习，总结病例特点，并对PG和MM并发可能的内在联系进行探讨，提示临床诊疗过程中需警惕PG和MM并发的现象，重视PG患者血液学指标的检测和MM患者的皮肤症状。

关键词: 大疱型坏疽性脓皮病, 多发性骨髓瘤, 来那度胺

Abstract: Pyoderma gangrenosum (PG) is a rare chronic ulcerative dermatosis, while multiple myeloma (MM) is a hematological malignancy with relatively high incidence. The concurrent occurrence of these two diseases is clinically rare, and their underlying association remains unclear. This paper reports a case of bullous PG complicating MM during lenalidomide maintenance therapy. The patient achieved complete resolution of skin lesions following treatment with methylprednisolone combined with cyclosporine A and doxycycline for 11 months, but MM recurrence was noted at 6-month follow-up and was treated with multiple therapentic regimens, such as VPd (pomalidomide+bortezomib+dexamethasone). Additionally, we reviewed 14 domestic and international articles on PG complicated with MM, summarized the clinical characteristics of the cases, and explored the potential relationship between the two diseases. These findings suggest that clinicians should be alert to the concurrent occurrence of PG and MM in clinical practice, and attach importance to hematological parameter detection in PG patients and skin symptom monitoring in MM patients.

Key words: bullous pyoderma gangrenosum, multiple myeloma, lenalidomide