中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (3): 185-189.doi: 10.12144/zgmfskin202603185

• 临床研究 • 上一篇    下一篇

阿布昔替尼治疗扁平苔藓三例并文献复习

邵泓源1,2*,张园1,2*,赵伟1,2,刘永霞1,2,田洪青1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022 *共同第一作者
  • 出版日期:2026-03-15 发布日期:2026-03-10

Abrocitinib in the treatment of lichen planus: three cases report and literature review

SHAO Hongyuan1,2*, ZHANG Yuan1,2*, ZHAO Wei1,2, LIU Yongxia1,2, TIAN Hongqing1,2   

  1. 1 Dermatology Hospital of Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China *Co-first authors
  • Online:2026-03-15 Published:2026-03-10

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摘要： 扁平苔藓是一种累及皮肤、指甲和黏膜的慢性炎症性疾病，有研究表明其发病机制与JAK/STAT 通路有关，且已有JAK 抑制剂治疗扁平苔藓有效的报道。本文3例扁平苔藓患者给予阿布昔替尼100 mg，每日一次。治疗4周后，2例患者皮疹完全消退，1例患者明显好转。

关键词: 扁平苔藓, 外阴扁平苔藓, 口腔扁平苔藓, 阿布昔替尼

Abstract: Lichen planus is a chronic inflammatory disease involving the skin, nails and mucous membranes. Studies have shown that its pathogenesis is associated with the JAK/STAT pathway, and there have been reports of JAK inhibitors exerting therapeutic effects on lichen planus. In this paper, 3 patients with lichen planus were administered abrocitinib at a dose of 100 mg once daily. After 4 weeks of treatment, complete resolution of skin lesions was observed in 2 patients, and significant improvement was noted in 1 patient.

Key words: lichen planus, vulvar lichen planus, oral lichen planus, abrocitinib