中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (4): 299-304.doi: 10.12144/zgmfskin202604299

• 综述 • 上一篇    下一篇

B细胞在化脓性汗腺炎发病机制中的研究进展

孙硕,赵莎莎,王颖,闫言   

  1. 中国医学科学院，北京协和医学院，整形外科医院皮肤科，北京，100144
  • 出版日期:2026-04-15 发布日期:2026-04-09

Research progress on the role of B cells in the pathogenesis of hidradenitis suppurativa

SUN Shuo, ZHAO Shasha, WANG Ying, YAN Yan   

  1. Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100144, China
  • Online:2026-04-15 Published:2026-04-09

PDF (PC)

27

摘要： 化脓性汗腺炎（HS）/反常性痤疮（AI）是一种累及毛囊皮脂腺的慢性炎症性皮肤病，好发于腋窝、腹股沟等间擦部位,初为疼痛性结节囊肿，后逐渐形成窦道和瘢痕，严重影响患者身心健康及生活质量。B细胞作为适应性免疫的重要组成部分，具有产生抗体、向T细胞呈递抗原等功能。B细胞激活、免疫复合物沉积和补体激活是HS免疫异常的重要环节，探究其在HS发病机制中的作用，有助于为HS的治疗寻找新靶点。本文旨在根据目前国内外研究现状，就B细胞在HS/AI发病的作用机制进行综述。

关键词: 化脓性汗腺炎, 反常性痤疮, B细胞

Abstract: Hidradenitis suppurativa (HS)/Acne inversa (AI) is an inflammatory systemic disease characterised by involvement of the pilosebaceous unit，predominantly affecting intimate areas of the body such as the axillary and inguinal sites. The disease initially presents as painful nodules and abscesses, which may progress to pus-discharging tunnels and scars, significantly impairing patients' quality of life. A pathway triggered by B cell activation, involving immune complex deposition and complement activation is considered the key of pathogenic mechanisms in HS. Understanding the role of B cells may offer new strategies in curing HS patients. Based on recent domestic and international research, this paper reviews current evidence on B cells in the pathogenesis of HS/AI.

Key words: hidradenitis suppurativa, acne inversa, B cells