中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (10): 705-709.doi: 10.12144/zgmfskin202610705

• 论著 • 上一篇    下一篇

大疱性系统性红斑狼疮三例并文献复习

刘凤琪1,薛紫涵1,马琳静1,夏育民1,武易2   

  1. 1 西安交通大学第二附属医院皮肤科，陕西西安，710004；2 空军军医大学西京医院第九八六医院检验科，陕西西安，710054
  • 出版日期:2026-10-15 发布日期:2026-10-09

Bullous systemic lupus erythematosus: a report of three cases and literature review

LIU Fengqi1, XUE Zihan1, MA Linjing1, XIA Yumin1, WU Yi2   

  1. 1 Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China; 2 Department of Clinical Laboratory, Xijing 986 Hospital, The Fourth Military Medical University, Xi'an 710054, China
  • Online:2026-10-15 Published:2026-10-09

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摘要： 本文报道3例大疱性系统性红斑狼疮，临床表现均为全身泛发性红斑及水疱。组织病理均显示为表皮下水疱，伴真皮层炎性细胞浸润，其中2例直接免疫荧光示IgG、IgM及/或IgA与补体C3在基底膜带呈线状沉积或颗粒状沉积。所有患者均接受糖皮质激素联合羟氯喹治疗，病情均获有效控制。本文还对既往文献进行分析，总结BSLE患者的临床表现及免疫学特征。

关键词: 大疱性系统性红斑狼疮, 系统性红斑狼疮, Ⅶ型胶原抗体

Abstract: Three female patients with bullous systemic lupus erythematosus (BSLE) were reported in this article. All patients presented with generalized erythema and blisters all over the body. Histopathological examination showed subepidermal blisters with inflammatory cell infiltration in the dermis. Direct immunofluorescence revealed linear or granular deposition of IgG, IgM and/or IgA together with complement C3 along the basement membrane zone in two cases. All patients were treated with glucocorticoids combined with hydroxychloroquine, and effective disease control was achieved. Previous literature was also analyzed to summarize the clinical manifestations and immunological features of patients with BSLE.

Key words: bullous systemic lupus erythematosus, systemic lupus erythematosus, type Ⅶ collagen antibody