中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (11): 792-795.doi: 10.12144/zgmfskin202611792

• 临床研究 • 上一篇    下一篇

先天性皮肤念珠菌病并发类白血病反应一例

龙宪川1,2,王坤2,陈燕2,罗丹2,邹静波3   

  1. 1重庆市永川区仙龙镇卫生院，重庆，402160；2重庆市永川区集嫒医院（永川区儿童医院），重庆，402160；3重庆市永川区疾病预防控制中心，重庆，402160
  • 出版日期:2026-11-15 发布日期:2026-10-29

Congenital cutaneous candidiasis complicated with leukemoid reaction: a case report

LONG Xianchuan1,2, WANG Kun2, CHEN Yan2, LUO Dan2, ZOU Jingbo3   

  1. 1 Chongqing Yongchuan District Xianlong Town Health Center, Chongqing 402160, China; 2 Chongqing Yongchuan District Ji'ai Hospital (Yongchuan District Children's Hospital), Chongqing 402160, China; 3 Chongqing Yongchuan District Center for Disease Control and Prevention, Chongqing 402160, China
  • Online:2026-11-15 Published:2026-10-29

PDF (PC)

10

摘要： 患儿，男，0小时17分钟，出生时出现全身皮肤广泛淡红色皮疹、呼吸急促、精神反应稍差等表现。诊断为新生儿肺炎、新生儿毒性红斑，予以抗生素治疗无效，期间出现类白血病反应。经皮损处分泌物涂片和培养检出白念珠菌，最终诊断为先天性皮肤念珠菌病，予以氟康唑、曲安奈德益康唑抗真菌治疗，患儿痊愈。先天性皮肤念珠菌病的临床症状缺乏特异性，容易误诊，对于抗生素治疗无效的新生儿，临床医生需要高度警惕本病，并进行相应病原学检查。

关键词: 先天性皮肤念珠菌病, 类白血病反应, 新生儿, 白色念珠菌

Abstract: A 17-minute-old male neonate presented with widespread skin lesions marked by pale red rashes，tachypnea, and mildly reduced mental responsiveness at birth. He was initially diagnosed with neonatal pneumonia and neonatal toxic erythema, but antibiotic therapy failed, and a leukemoid reaction emerged during treatment. Candida albicans was detected through smear and culture of secretions from the skin lesions, confirming a final diagnosis of congenital cutaneous candidiasis. The neonate responded well to antifungal therapy, including fluconazole and triamcinolone acetonide econazole. Because the clinical features of congenital cutaneous candidiasis are nonspecific, misdiagnosis is common. Clinicians should consider this condition in neonates unresponsive to antibiotics and conduct appropriate etiological investigations.

Key words: congenital cutaneous candidiasis, leukemoid reaction, neonate, Candida albicans