中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (11): 813-814.doi: 10.12144/zgmfskin202611813

• 病例报告 • 上一篇    下一篇

尿液RNA恒温扩增诊断淋球菌性尿道炎一例

孙嘉忆1,2,孙远航1,2,李珍1,2,初同胜1,2,暴芳芳1,2,田洪青1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2026-11-15 发布日期:2026-10-29

Urine RNA isothermal amplification in the diagnosis of gonococcal urethritis: a case report

SUN Jiayi1,2, SUN Yuanhang1,2, LI Zhen1,2, CHU Tongsheng1,2, BAO Fangfang1,2, TIAN Hongqing1,2   

  1. 1 Dermatology Hospital of Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2026-11-15 Published:2026-10-29

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摘要： 患者，男，45岁，尿道脓性分泌物、排尿痛及尿道疼痛3天就诊。尿液实时荧光核酸恒温扩增检测（simultaneous amplification and testing，SAT）示淋病奈瑟菌RNA阳性；尿道分泌物革兰染色示大量多形核白细胞及细胞内革兰阴性双球菌，培养分离出淋病奈瑟菌，药敏结果提示对头孢曲松及头孢克肟敏感。依据中国指南予头孢曲松1 g肌内注射单次治疗。用药7天后复诊，患者症状明显改善，尿道分泌物镜检及培养均为阴性，尿液SAT亦转阴。

关键词: 淋病, 淋球菌性尿道炎, 淋病奈瑟菌, 实时荧光核酸恒温扩增检测, 抗菌药物敏感性

Abstract: We report a case of gonococcal urethritis in a 45-year-old man who presented with a 3-day history of purulent urethral discharge, dysuria, and urethral pain. Urine was tested for N. gonorrhoeae RNA using simultaneous amplification and testing (SAT), with a positive result. Gram staining of the urethral discharge showed numerous polymorphonuclear leukocytes and intracellular Gram-negative diplococci. Culture yielded Neisseria gonorrhoeae, and antimicrobial susceptibility testing demonstrated susceptibility to ceftriaxone and cefixime. The patient was treated with a single 1 g intramuscular dose of ceftriaxone according to the Chinese guideline. At the 7-day follow-up visit after treatment, his symptoms had improved markedly, and urethral microscopy, culture, and repeat urine SAT were all negative.

Key words: gonorrhea, gonococcal urethritis, Neisseria gonorrhoeae, simultaneous amplification and testing, antimicrobial susceptibility