中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (1): 11-13.

• 论著 • 上一篇    下一篇

银屑病患者外周血TL1A及其受体DcR3的表达

缪泽群 宋继权 张丽芳 郑楷平 宋 韬 盛晚香   

  1. 湖南大学中南医院皮肤科
  • 出版日期:2016-01-15 发布日期:2018-12-13

The level of TL1A and its receptor DcR3 in the peripheral blood of patients with psoriasis vulgaris

MIAO Ze-qun, SONG Ji-quan，ZHANG Li-fang，ZHENG Kai-ping, SONG Tao, SHENG Wan-xiang.   

  1. Department of Dermatology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
  • Online:2016-01-15 Published:2018-12-13

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摘要： 目的：检测肿瘤坏死因子样配体1A(TL1A)及其受体DcR3在寻常型银屑病患者外周血中的表达。方法：采用酶联免疫吸附试验(ELISA)检测30 例寻常型银屑病患者及30例健康对照者血清中TL1A及其受体DcR3的水平。结果：银屑病组外周血TL1A和DcR3水平分别为（478.21±231.18）pg/mL和（638.31±310.73）pg/mL，显著高于对照组的（125.67±82.85）pg/mL和（245.16±111.52）pg/mL (P＜0.05)。进行期患者TL1A和DcR3水平分别为（584.91±298.52）pg/mL和（860.41±402.78）pg/mL，显著高于静止期患者的（261.73±120.84）pg/mL和（467.34±225.16）pg/mL（P＜0.05)；银屑病患者组外周血TL1A与DcR3水平呈正相关。结论： 银屑病患者外周血清TL1A及其受体DcR3水平显著升高，TL1A可能通过与其受体DcR3结合参与银屑病的发生与发展。

关键词: 银屑病, 肿瘤坏死因子样配体1A, 诱骗受体3

Abstract: Objectives: To detect the level of TL1A and its receptor DcR3 in the peripheral blood of patients with psoriasis vulgaris. Methods: The level of serum L1A and its receptor DcR3 was detected by enzyme linked immunosorbent assay ( ELISA) in 30 patients with psoriasis vulgaris and 30 healthy controls．Results: The level of serum TL1A and its receptor DcR3 in the patients was 478.21±231.18 pg/mL and 638.31±310.73 pg/mL, which were higher than those in healthy controls （125.67±82.85 pg/mL and 45.16±111.52 pg/mL）(P＜0.05) and those in the patients of progressive stage were 584.91±298.52 pg/mL and 860.41±402.78 pg/mL, which were higher than those in the patients of stable stage （261.73±120.84 pg/mL and 67.34±225.16 pg/mL）（P＜0.05). The level of TL1A in the patients with psoriasis vulgaris was positively correlated with DcR3 (P＜0.05). Conclusion: The level of TL1A and its receptor DcR3 in the peripheral blood of patients with psoriasis vulgaris was significantly increased and TL1A may play important roles in the progress of psoriasis vulgaris by combining with its receptor DcR3.

Key words: psoriasis, TNF-like ligand 1 aberrance, decoy receptor 3