中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (1): 22-23.

• 短篇论著 • 上一篇    下一篇

玫瑰糠疹患者外周血IL-17和IL-22的表达

周琼艳1 叶小磊2 许素玲1 彭 岚3   

  1. 1 宁波大学医学院附属医院皮肤科，浙江宁波，315020 2 宁波市医学科学研究所药物与药理研究室，浙江宁波，315020 3 宁波大学医学院附属医院检验科，浙江宁波，315020
  • 出版日期:2016-01-15 发布日期:2018-12-13
  • 基金资助:
    基金项目：宁波大学校级科研项目(编号：XYY13003)

Expression of IL-17 and IL-22 in the patients with pityriasis rosea

ZHOU Qiong-yan1, YE Xiao-lei2, XU Su-ling1, PENG Lan3   

  1. Department of Dermatology, the Affiliated Hospital of Medical College of Ningbo University, Ningbo 315020, China
  • Online:2016-01-15 Published:2018-12-13

PDF (PC)

127

摘要： 目的：检测外周血IL-17和IL-22在玫瑰糠疹患者中的水平。方法：采取酶联免疫(ELISA)双抗体夹心法，检测45例玫瑰糠疹急性期患者、45例恢复期患者和45名健康人外周血中IL-17和IL-22的水平。结果：玫瑰糠疹急性期、恢复期患者与正常对照组外周血IL-17浓度分别为45.08±14.34 pg/mL，29.34±11.88 pg/mL，15.51±8.79 pg/mL；IL-22浓度分别为85.43±20.01 pg/mL，61.26±10.37 pg/mL，50.54±13.28 pg/mL。三组IL-17和IL-22水平比较差异有统计学意义(P＜0.05)。结论：玫瑰糠疹急性期及恢复期患者均存在IL-17和IL-22的表达异常，该疾病可能存在Th17细胞亚群失衡。

关键词: 玫瑰糠疹, ELISA, IL-17, IL-22

Abstract: Objective: To detect the serum level of IL-17 and IL-22 in patients with pityriasis rosea onset. Method: The levels of IL-17 and IL-22 were detected by ELISA in patients with pityriasis rosea (45 patients in the acute stage, 45 patients in the recovery stage) and 45 healthy controls. Results: The level of IL-17 of pityriasis rosea patients with acute period, recovery stage and healthy controls was (45.08±14.34) pg/mL, (29.34±11.88) pg/mL and (15.51±8.79) pg/mL respectively, with significant differences (P<0.05); IL-22 was (85.43±20.01) pg/mL，(61.26±10.37) pg/mL and (50.54±13.28) pg/mL respectively, with significant differences (P<0.05). Conclusion: The expression levels of IL-17 and IL-22 of pityriasis rosea in acute period and recovery stage are both increased, which may indicate the imbalance of Th17 cell subsets in pityriasis rosea.

Key words: pityriasis rosea, ELISA, IL-17, IL-22