中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (2): 70-73.

• 论著 • 上一篇    下一篇

CD103+T细胞在银屑病皮损中的表达

郝志敏 栾超 胡煜 杨永红 刘毅 陈敏 崔盘根   

  1. 中国医学科学院皮肤病医院，江苏省皮肤病与性病分子生物学重点实验室 南京，210042
  • 出版日期:2016-02-15 发布日期:2018-12-17
  • 通讯作者: 陈敏，E-mail:?drchenmin@126.com 崔盘根，E-mail: pangencui@126.com
  • 基金资助:
    卫生公益性行业科研专项经费项目（编号：201002016）

Expression of CD103 + T cells in psoriatic lesions

HAO Zhimin，LUAN Chao, HU Xu, YANG Yonghong, LIU Yi, CHEN Min，CUI Pangen.   

  1. Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Online:2016-02-15 Published:2018-12-17
  • Contact: CHEN Min, E-mail: drchenmin@126.com CUI Pangen E-mail: pangencui@126.com

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摘要： 目的：明确银屑病患者皮肤CD103+T细胞的表达及其与银屑病严重程度的关系。方法：免疫组化检测29例银屑病患者皮损和非皮损皮肤及6名健康对照皮肤中表皮及真皮CD103+T细胞的表达。计算银屑病患者PASI值。结果：CD103+T细胞主要在真皮表达。银屑病患者皮损和非皮损真皮中每个高倍视野CD103+T细胞百分率分别为（26.06%±11.72）%和（12.82±4.5）%（P<0.05）；健康人对照皮肤真皮内CD103+T细胞百分率为（7.47±1.3）%，明显低于银屑病非皮损区（P<0.05）。银屑病患者皮损中，CD103+T的表达与PASI值正相关（P<0.05）。 结论：真皮中CD103+T细胞可能与银屑病的发病及严重程度有关。

关键词: 银屑病, CD103+T细胞, 免疫组化

Abstract: Objective: To detect the level of CD103+T lymphocytes in psoriatic lesions and to determine the relationship with the severity of psoriasis. Methods: CD103+T lymphocytes in dermis?and?epidermis of the lesions and non-lesional skin from 29 patients with psoriasis and skin from 6 healthy controls were detected by immunohistochemical staining. Results：CD103+T lymphocytes mainly distributed in dermis. The mean percentage of CD103+T lymphocytes in lesions, non-lesional skin and normal skin was (26.06±11.72%), (12.82±4.50%) and (7.47±1.30%) and there?were significant differences among the groups (P<0.05). There was a positive correlation between the level of CD103+T lymphocytes and the PASI score (P<0.05). Conclusion：CD103+T lymphocytes in the dermis may associate with the occurrence and severity of psoriasis.

Key words: psoriasis, CD103+T lymphocytes, immunohistochemical staining