中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (6): 342-345.

• 短篇论著 • 上一篇    下一篇

内蒙古汉族寻常型银屑病REL基因多态位点检测

王 勇1，韩建文2，白云花3，孙志强2，阿拉腾楚鲁2，刘 佳2，李东霞2，吕新翔2，乌日娜2   

  1. 内蒙古医科大学附属医院风湿科，呼和浩特，010050 2内蒙古医科大学附属医院皮肤科，呼和浩特，010050 3呼伦贝尔市人民医院皮肤科，呼伦贝尔市，021000
  • 出版日期:2016-06-15 发布日期:2018-12-27
  • 通讯作者: 韩建文，E-mail: hanjianwen1981@hotmail.com
  • 基金资助:

    基金项目：国家自然科学基金（31160192）；内蒙古医科大学青年创新基金项目（NY2011QN005）；内蒙古自治区卫生和计划生育委员会医疗卫生科研计划项目（201303057）；内蒙古自治区高等学校“青年科技英才支持计划”（NJYT-14-B17）

     

Detection of the polymorphisms of REL gene in the patients with psoriasis vulgaris in Han nationality of Inner Mongolia

WANGYong 1, HAN Jianwen 2, BAI YunHua 3, SUN Zhiqiang 2, ALATENG Chulu 2, LIU Jia 2, LIDongxia2, LV Xinxiang2, WU Rina2.   

  1. 1. Department of Rheumatology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China; 2. Department of Dermatology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China 3. Department of Dermatology, Hulunbeier People’s Hospital, Hulunbeier 021000, China
  • Online:2016-06-15 Published:2018-12-27
  • Contact: HAN Jianwen, E-mail: hanjianwen1981@hotmail.com

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摘要： 目的：检测内蒙古汉族人寻常型银屑病（PsV）患者禽网状内皮组织增殖病毒癌基因V-Rel同源基因（REL）的多态性。方法：提取301例PsV患者及292例正常对照外周血DNA，利用连接酶检测反应检测REL基因区域的4个单核苷酸多态性（SNP）（rs702873、rs842636、rs13031237 和 rs13017599）。结果：PsV患者rs702873和rs842636的等位基因频率分别为0.126和0.128，对照组中分别为0.182和0.181，差异有统计学意义(P<0.05)且rs702873和rs842636间存在强连锁不平衡（D’=0.993，r2=0.980）。rs13031237和rs13017599等位基因频率在PsV患者和对照组中差异无统计学意义(P>0.05)。结论：REL基因位点（rs702873和rs842636）多态性可能与内蒙古汉族人PsV的易感性相关。

关键词: 寻常型银屑病, 单核苷酸多态性

Abstract: Objective: To detect the polymorphisms of REL (v-rel avian reticuloendotheliosis viral oncogene homolog) in Han nationality of Inner Mongolia. Methods：DNA was extracted from the peripheral blood of 301 patients and 292 healthy controls. The polymorphisms of REL gene (rs702873, rs842636, rs13031237 and rs13017599) were genotyped by PCR-based ligase detection reaction (PCR-LDR). Results: The genotype frequencies of rs702873 and rs842636 in the patients were 0.126 and 0.128 and those in controls were 0.182 and 0.181, with significant difference (P<0.05) .There was a linkage disequilibrium of rs702873 and rs842636. There was no significant difference in rs13031237 and rs13017599 between the patients and controls (P>0.05). Conclusions: The polymorphisms of REL gene (rs702873 and rs842636) are associated with psoriasis vulgaris in Han nationality of Inner Mongolia.

Key words: psoriasis vulgaris, single nucleotide polymorphisms