NB-UVB联合8-MOP PUVA治疗小腿斑块状银屑病疗效评价

中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (6): 351-353.

NB-UVB联合8-MOP PUVA治疗小腿斑块状银屑病疗效评价

王娜1 单晓峰 1 杨宝琦1 吴卫志1 刘素琴1 颜世富2

1山东省皮肤病性病防治研究所，济南，250022 2新泰市中医院，泰安，271200

出版日期:2016-06-15 发布日期:2018-12-27
通讯作者: 王娜，E-mail：masterwangna@126.com

Efficacy of NB-UVB combined with 8-MOP PUVA in the treatment of psoriasis vulgaris

WANG Na1, SHAN Xiaofeng1, YANG Baoqi1, WU Weizhi1, LIU Suqin1, YAN Shifu2.

1.Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China; 2.Xintai Municipal Hosapital of Traditional Chinese Medicine, Taian 271200, China

Online:2016-06-15 Published:2018-12-27
Contact: WANG Na, E-mail：masterwangna@126.com

摘要/Abstract

摘要： 目的: 评价NB-UVB联合8-甲氧补骨脂素（8-MOP） PUVA治疗斑块状银屑病的疗效。方法: 分别对16例银屑病患者双侧小腿进行PASI评分，一侧给予NB-UVB照射，另一侧给予NB-UVB联合8-MOP PUVA，每周3次，共治疗20次。结果: NB-UVB治疗侧治疗前后PASI评分分别为8.21±2.97和2.31±1.01，差异有统计学意义(P＜0.05)；NBUVB联合8-MOP PUVA治疗侧分别为8.33±2.54和1.20±0.93，差异有统计学意义(P＜0.05)。治疗后NBUVB联合8-MOP 治疗侧较NB-UVB治疗侧PASI更低,差异有统计学意义(P＜0.05)。结论：NB-UVB联合8-MOP PUVA可明显促进小腿顽固部位皮损的消退。

关键词: NB-UVB, 8-MOP PUVA, 银屑病, 斑块

Abstract: Objective: To assess the efficacy of NB-UVB combined with 8-MOP PUVA in the treatment of psoriasis vulgaris on lower legs. Methods: The PASI of lesions on lower legs of 16 patients was assessed. One side of the lower legs of the patients was treated with NB-UVB and another side was treated with NB-UVB combined with PUVA, three times a week, 20 times totally. Results: The PASI of the lesions treated with NB-UVB before and after treatment were 8.21±2.97 and 2.31±1.01, with significant difference (P＜0.05) and the lesion treated with NB-UVB combined with PUVA were 8.33±2.54 and 1.20±0.93, with a significant difference (P＜0.05) . The PASI of the lesions treated with NB-UVB combined with PUVA was lower than that of the lesion treated with NB-UVB alone, with a significant difference (P＜0.05) . Conclusion: NB-UVB combined with PUVA is more effective than NB-UVB alone in the treatment of psoriatic plaque on legs.

Key words: NB-UVB, cream PUVA, psoriasis, plaque

王娜, 单晓峰, 杨宝琦, 吴卫志, 刘素琴, 颜世富. NB-UVB联合8-MOP PUVA治疗小腿斑块状银屑病疗效评价[J]. 中国麻风皮肤病杂志, 2016, 32(6): 351-353.

WANG Na, SHAN Xiaofeng, YANG Baoqi, WU Weizhi, LIU Suqin, YAN Shifu.. Efficacy of NB-UVB combined with 8-MOP PUVA in the treatment of psoriasis vulgaris [J]. China Journal of Leprosy and Skin Diseases, 2016, 32(6): 351-353.

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