中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (7): 394-396.

• 论著 • 上一篇    下一篇

Klf4在银屑病和湿疹患者皮损中的表达

郭坤,肖生祥,耿松梅   

  1. 西安交通大学第二附属医院皮肤病院,西安,710004
  • 出版日期:2016-07-15 发布日期:2018-12-21
  • 通讯作者: 耿松梅,E-mail:gsm312@yahoo.com

Expression of Klf4 in the lesions of the patients with psoriasis or eczema

GUO Kun, XIAO Shengxiang, GENG Songmei   

  1. Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China
  • Online:2016-07-15 Published:2018-12-21
  • Contact: GENG Songmei, E-mail: gsm312@yahoo.com

摘要: 目的:检测Klf4在银屑病及湿疹皮损中的表达。方法:采用免疫组化技术检测Klf4在16例银屑病患者皮损、16例湿疹皮损及16例正常皮肤中的表达。结果:银屑病皮损Klf4阳性细胞数为(346.56±24.91)高于正常皮肤的(235.12±20.32),(P<0.05),湿疹皮损为(75.94±15.61),低于正常皮肤(P<0.05)。结论:湿疹患者的Klf4表达下调而在银屑病患者中上调,KIf4在不同疾病中可能发挥不同的生物学作用。

关键词: Klf4, 银屑病, 湿疹

Abstract: Objective: To detect the expression levels of Klf4 in the lesions of the patients with psoriasis or eczema. Methods:The expression levels of Klf4 in the lesions of psoriasis or eczema was detected by immunohistochemistry methods. Results: The average number of KIf4 positive cells in the psoriatic lesions was (346.5624.91), which was higher than that in the normal skin (235.12±20.32), with a significant difference (P<0.05). The average number of KIf4 positive cells in the eczema lesions was (75.94±15.61), which was lower than that in normal skin (P<0.05). Conclusion: Klf4 was down-regulated in patients with eczema and was up-regulated in the patients with psoriasis. Klf4 may play a different role in the pathogenesis of different diseases.

Key words: Klf4, psoriasis, eczema