中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (9): 517-519.

• 论著 • 上一篇    下一篇

新生儿梅毒12例临床研究

刘盼盼1，李 静2，陈梦琳1，朱 武1   

  1. 1，中南大学湘雅医院皮肤科，湖南长沙，410008 2，中南大学湘雅医院神经内科，湖南长沙，410008
  • 出版日期:2016-09-15 发布日期:2018-12-14
  • 通讯作者: 朱武，E-mail：zhuwu70@hotmail.com

Clinical research of 12 cases with congenital syphilis

LIU Panpan1, LI Jing2, CHEN Menglin1, ZHU Wu1   

  1. 1. Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China； 2. Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
  • Online:2016-09-15 Published:2018-12-14
  • Contact: ZHU Wu, E-mail：zhuwu70@hotmail.com

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摘要： 目的：分析新生儿梅毒的临床特点。方法：对12例新生儿梅毒患者的临床资料进行回顾性分析。结果：本组首发症状为：窒息（3例）、气促发绀（2例）、四肢活动障碍（1例）、皮肤黄染（1例）、抽搐（1例）；4例无症状；合并肝脾肿大6例，贫血2例，皮疹2例。12例患者血清TPHA检测均阳性，11例患儿脑脊液生化异常或TPHA阳性，脑脊液生化以蛋白异常为多见；5例患儿血清中监测到病毒IgM抗体，以EB病毒感染最常见。结论：新生儿梅毒临床表现复杂多样，神经系统容易受累,易合并病毒感染。

关键词: 新生儿梅毒, 临床特点, 神经梅毒

Abstract: Objective：To analyze the clinical features of congenital syphilis（CS）. Methods：The clinical data of 12 patients with CS were analyzed retrospectively. Results：The initial symptoms of 12 congenital syphilis patients included choke (3 cases), polypnea and cyanosis (2 cases), quadriplegia（1 case），xanthochromia（1 case）, convulsion（1 case）and asymptom（4 cases）. Hepatosplenomegaly was seen in 6 cases，anemia in 2 and rash in 2. Treponema pallidum hemagglutination assay (TPHA) test of serum samples was positive in all the 12 patients. Increase in WBC count or protein elevation or positivity of TPHA in cerebrospinal fluid were positive in11 cases. Many kinds of virus antibody-IgM were detected in the sera of 5 patients, especially EB virus.

Key words: congenital syphilis, clinical features, neurosyphilis