中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (6): 348-351.

• 论著 • 上一篇    下一篇

MCPIP1和IL-17c在寻常型银屑病皮损中的表达

姚婉玉  唐秀生   

  1. 右江民族医学院附属医院皮肤科，广西百色，533000
  • 出版日期:2017-06-15 发布日期:2018-12-14
  • 通讯作者: 唐秀生，E-mail: tangxsh6199@126.com

Expression of MCPIP1 and IL-17c in the lesions of the patients with psoriasis vulgaris

YAO Wanyu, TANG Xiusheng.   

  1. Department of Dermotology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China
  • Online:2017-06-15 Published:2018-12-14
  • Contact: TANG Xiusheng, E-mail: tangxsh6199@126.com

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摘要： 目的：检测MCPIP1和IL-17c在寻常型银屑病患者皮损中的表达。方法：Real-time PCR及免疫荧光检测45例寻常型银屑病患者皮损及19例正常皮肤中MCPIP1和IL-17c mRNA及蛋白表达水平，皮尔逊相关系数分析MCPIP1和IL-17c的相关性。结果：银屑病组MCPIP1、 IL-17c mRNA相对表达量分别为0.8497±0.0661和0.4027±0.04158，对照组中分别为0.2921±0.06135和0.2374±0.02525， 差异均有统计学意义(P<0.05)。MCPIP1和IL-17c mRNA水平具有明显相关性(P<0.05)。患者组皮损中MCPIP1和IL-17c的蛋白表达水平高于正常对照组。结论：MCPIP1和IL-17c可能共同影响寻常型银屑病的发生发展。

关键词: 寻常型银屑病, MCPIP1, IL-17c

Abstract: Objective: To detect the expression of MCPIP1 and IL-17c in the lesions of the patients with psoriasis vulgaris. Methods: The expression levels of MCPIP1 and IL-17c mRNA and protein in the lesions of the patients with psoriasis vulgaris and the normal skin samples in 19 controls were detected by Real-time PCR and immunofluorescence technique. The association between the levels of MCPIP1 and IL-17c in the patients were assessed by Pearson correlation coefficient. Results: The level of MCPIP1 and IL-17c in the lesions was 0.8497±0.0661 and 0.4027±0.04158, which was higher than those in controls (0.2921±0.06135 and 0.2374±0.02525) with significant differences (P<0.05). There was obvious correlation between the level of MCPIP1 and IL-17c mRNA. The protein level of MCPIP1 and IL-17c in the lesions was higher than that in normal controls. Conclusion: MCPIP1 can interact with IL-17c, which influences the development of psoriasis.

Key words: psoriasis vulgaris, MCPIP1, IL-17c