中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (7): 440-443.

• 综述 • 上一篇    下一篇

SOCS调控树突状细胞在炎症性皮肤病中的作用机制研究进展

李天航1  史冬梅1，2   

  1. 1济宁市第一人民医院皮肤科,山东济宁,272001
    2中国医学科学院皮肤病研究所,江苏南京,210042
  • 出版日期:2017-07-15 发布日期:2018-12-03
  • 通讯作者: 史冬梅，E-mail: shidongmei28@163.com

Update of the mechanism of dendritic cells regulated by SOCS in inflammatory diseases

LI Tianhang, SHI Dongmei.   

  1. 1. Department of Dermatology, Jining NO.1 People's Hospital, Jining 272001, Shandong, China; 2. Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, 210042, Nanjing, China
  • Online:2017-07-15 Published:2018-12-03
  • Contact: SHI Dongmei, E-mail: shidongmei28@163.com

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摘要： 细胞因子信号抑制因子基因可通过对树突状细胞成熟分化的调控，影响免疫应答的平衡稳定，在炎症性疾病的发生、发展中具有重要影响。本文就细胞因子信号抑制因子基因调控树突状细胞在银屑病、类风湿性关节炎、系统性红斑狼疮、真菌感染等炎症性疾病中的作用机制研究进展进行综述。

关键词: 细胞因子信号抑制因子, 树突状细胞, 调控, 炎症性疾病

Abstract: Cytokine signaling suppressive gene plays an important role in the development of inflammatory diseases, through regulating the balance of the immune response, and differentiation and maturation of the dendritic cells. This article reviews the recent researches on the mechanism of dendritic cells regulated by SOCS in psoriasis, rheumatoid arthritis, systemic lupus erythematosus and fungal infection.

Key words: suppressor of cytokine signaling, dendritic cells, regulate, inflammatory disease