中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (6): 350-352.

• 短篇论著 • 上一篇    下一篇

头孢曲松钠联合阿立哌唑治疗神经梅毒伴发精神症状的疗效评价

郭鹏1宋树玲2   

  1. 1.山东省枣庄市皮肤病性病防治院，山东枣庄，277599 2.枣庄市立医院，山东枣庄，277102
  • 出版日期:2018-06-15 发布日期:2018-12-11

Efficacy of ceftriaxone sodium combined with aripiprazolein in the treatment of psychiatric symptoms of the patients with neurosyphilis

GUO Peng1，SONG Shuling2   

  1. 1 Zaozhuang Institute of Dermatology and Venereology, Zaozhuang 277599, Shandong, China; 2. Zaozhuang Municipal Hospital, Zaozhuang 277100, Shandong, China
  • Online:2018-06-15 Published:2018-12-11

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摘要： 目的：评价神经梅毒伴发精神症状患者应用头孢曲松钠联合阿立哌唑治疗的效果。方法：对我院2013年2月至2014年9月收治的神经梅毒伴发精神症状患者给予头孢曲松钠静滴，1次/天，2g/次，连续2周，联合口服阿立哌唑治疗， 10～15mg/次，1次/天，依病情及耐受程度，调整剂量，最大剂量为30mg/次，连续服用6周。记录阳性与阴性综合征量表（PANSS）评分、临床疗效总评量表病情严重程度（CGI-SI）评分及不良反应，随访3年。结果：共治疗64例患者，治疗6周后，PANSS一般精神症状评分、阴性症状评分、总评分均及CGI-SI评分均降低，与治疗前比较，差异具有显著性（均P＜0.05）。精神症状改善总有效率为65.63%（42/64）。患者不良反应发生率为14.06%（9/64），且都属于轻度不良反应。随访3年，患者RPR转阴率为96.88%（62/64），脑脊液正常率98.44%（63/64），复发率为4.69%（3/64）。结论：神经梅毒伴发精神症状患者应用头孢曲松钠联合阿立哌唑治疗可以有效改善患者精神症状，具有良好的安全性。

关键词: 神经梅毒, 精神症状, 头孢曲松钠, 阿立哌唑

Abstract: To assess the efficacy of ceftriaxone sodium combined with aripiprazolein in the treatment of psychiatric symptoms of the patients with neurosyphilis. Methods: The cases of neurosyphilis with psychiatric symptoms in our hospital from February 2013 to September 2014 were collected. All patients were given intravenous infusion of ceftriaxone sodium, 2g, once a day, for 2 weeks, combined with oral aripiprazole, 10-15mg, once a day, for 6 weeks. The Negative Syndrome Scale (PANSS) score, symptoms of mental illness the clinical global impression scale severity score (CGI-SI). Adverse reactions were recorded. All the patients were followed up for 3 years. Results: Six four patients were collected. The general psychiatric symptoms score, positive symptom score and total score of PANSS and CGI-SI score decreased in the patients after treated for 6 weeks and there was significant differences compared with those before treatment (Ps<0.05). The total clinical effective rate of mental symptoms was 65.63% (42/64). The adverse reaction in the patients was 14.06% (9/64), and all the adverse reactions were mild. After 3 years of follow-up, the negativity rate of RPR in the 64 patients was 96.88% (62/64), the normal rate of cerebrospinal fluid was 98.44%（63/64）and the recurrence rate was 4.69% (3/64). Conclusion: Ceftriaxone sodium combined with aripiprazole in the treatment of psychiatric symptoms of the patients with neurosyphilis is effective and safe.

Key words: neurosyphilis, psychiatric symptoms, ceftriaxone sodium, aripiprazole