中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (8): 473-474.

• 论著 • 上一篇    下一篇

Ａ型肉毒毒素治疗带状疱疹后神经痛疗效评价

朱明明 1 刘科峰2   

  1. 1.新乡医学院第三附属医院皮肤科， 河南新乡， 453003 2.河南大学第一附属医院皮肤科， 河南开封， 475000
  • 出版日期:2018-08-15 发布日期:2018-12-11
  • 通讯作者: 刘科峰，E-mail: liukefengys@163.com

Efficacy of botulinum toxin type A in the treatment post-herpetic neuralgia

ZHU Mingming1, LIU Kefeng2   

  1. 1. Department of Dermatology，the Third Affiliated Hospital of XinXiang Medical of College，XinXiang 453003，Henan, China; 2. The First Hospital Affiliated to Henan University,Kaifeng 475001,China
  • Online:2018-08-15 Published:2018-12-11
  • Contact: LIU Kefeng, E-mail: liukefengys@163.com

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摘要： 目的: 评价皮内注射Ａ型肉毒毒素治疗疱疹后遗神经痛(PHN)的疗效。方法: PHN患者随机分为观察组和对照组,观察组:皮下注射含100单位肉毒素A的生理盐水4mL；对照组:皮下注射曲安奈德注射液+利多卡因注射液 1:1, 4mL。 计算治疗前后痛症状严重程度评分(VAS)。结果: 65例PHN患者，随机分为观察组27例和对照组38例。8周后治疗组和对照组VAS分别为2.72±1.37和4.53±2.20，两组比较差异有统计学意义（P<0.05）， 观察组有效率96.2%，优于对照组76.3%，差异有统计学意义(P<0.05)。 结论: 皮内注射Ａ型肉毒素治疗PHN优于曲安奈德局部封闭。

关键词: Ａ型肉毒毒素, 带状疱疹后神经痛;曲安奈德

Abstract: Objective: To assess the efficacy of botulinum toxin type A in the treatment of post-herpetic neuralgia (PHN). Method: The patients with PHN were divided into the observation groupand the control group randomly. The patients in the observation group were treated with subcutaneous injection of saline 4mL containing 100 units botulinum toxin type A. Those in the control group were treated with triamcinolone injection and lidocaine injection with ratio 1:1, 4mL. Severity of pain symptoms (VAS) before and after treatment was assessed. Result：Sixty five cases were collected, including 27 in the observation group and 38 in the control group. After treatment for 8 weeks, the VAS in the observation group and the control group was 2.72±1.37and 4.53±2.2, with a significant difference (P<0.05). The effective rate in the observation group and control group was 96.2% and 76.3% with a significant difference (P<0.05). Conclusion：Botulinum toxin type A in the treatment of PHN is more effective than triamcinolone.

Key words: botulinum toxin type A, post-herpetic neuralgia, triamcinolone acetonide