中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (1): 15-17.doi: 10.12144/zgmfskin202301015

• 论著 • 上一篇    下一篇

阿达木单抗治疗坏疽性脓皮病一例并文献复习

臧箫,李洪达,刘永霞,卢宪梅,杨青,王伟伟,吴卫志   

  1. 山东第一医科大学附属皮肤病医院（山东省皮肤病医院），山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2023-01-15 发布日期:2022-11-25

Pyoderma gangrenosum successfully treated with adalimumab: a case report and literature review

ZANG Xiao, LI Hongda, LIU Yongxia, LU Xianmei, YANG Qing, WANG Weiwei, WU Weizhi   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Veneorology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2023-01-15 Published:2022-11-25

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摘要： 报道阿达木单抗成功治疗一例坏疽性脓皮病，并进行文献复习。患者，男，53岁。左股内侧红斑、丘疹6个月，溃疡3个月。组织病理示：符合坏疽性脓皮病。给予雷公藤多苷片、沙利度胺片治疗3天，仍有新发红斑、丘疹，于第3天、第10天分别给予皮下注射阿达木单抗80 mg、40 mg，后每2周皮下注射阿达木单抗40 mg，注射第4剂阿达木单抗时溃疡已愈合。半年后随访，皮损未复发。

关键词: 抗TNF-α拮抗剂, 阿达木单抗, 坏疽性脓皮病

Abstract: A case of pyoderma gangrenosum successfully treated with adalimumab was reported and relevant literatures are reviewed. The case was a 53-year-old male with erythema and papules on the left inner thigh for 6 months and ulcers for 3 months. The pathological features were accordance with pyoderma gangrenosum.  He was treated with tripterygium wilfordii polyglycosides and thalidomide tablets on the first day after being diagnosed, but there were still new erythema and papules after 3 days. Adalimumab 80mg and 40mg were given on the third day and the 10th day respectively. Then, adalimumab was injected subcutaneously, 40mg, every 2 weeks, and the ulcer healed when the fourth dose of adalimumab was injected.The skin lesions did not recur after six months of follow-up.

Key words: TNF-alpha antagonist, adalimumab, pyoderma gangrenosum