中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (10): 749-753.doi: 10.12144/zgmfskin202410749

• 综述 • 上一篇    下一篇

皮肤类器官构建及应用研究进展

彭嘉怡,王洪生   

  1. 中国医学科学院 北京协和医学院皮肤病医院皮肤病研究所，江苏南京，210042
  • 出版日期:2024-10-15 发布日期:2024-08-29

Update of generation and application of skin organoids

PENG Jiayi, WANG Hongsheng   

  1. Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Online:2024-10-15 Published:2024-08-29

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摘要： 皮肤类器官是由多能干细胞分化形成的与皮肤成分和功能相似的结构。研究表明皮肤类器官可应用于研究皮肤疾病发病机制、药物筛选及皮肤损伤修复。本文就近年来皮肤类器官的构建方法及其在皮肤疾病研究及再生医学中的应用进行综述。

关键词: 皮肤, 类器官, 三维, 多能干细胞, 再生医学

Abstract: Skin organoids are in vitro models equivalent to the structure and function of the skin. Recent study has shown that skin organoids can be applied to investigate the pathogenesis of cutaneous diseases, drug screening, and wound repair. This review aims to summarize current study on the construction of skin organoids, their application on skin diseases and regenerative medicine.

Key words: skin, organoid, three dimension, pluripotent stem cell, regenerative medicine