中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (4): 289-291.doi: 10.12144/zgmfskin202404289

• 病例报告 • 上一篇    下一篇

透明细胞软骨肉瘤术后皮肤和内脏多发性转移一例

宋寒清1,程寅1,洪心怡1,王秀琴1,郭泽1,李卉1,李莉2,王培光1   

  1. 1安徽医科大学第一附属医院皮肤性病科，安徽合肥，230022；2安徽医科大学第一附属医院病理科，安徽合肥，230022
  • 出版日期:2024-04-15 发布日期:2024-03-26

Multiple cutaneous and visceral metastases from clear cell chondrosarcoma after operation: a case report

SONG Hanqing1, CHENG Yin1, HONG Xinyi1, WANG Xiuqin1, GUO Ze1, LI Hui1, LI Li2, WANG Peiguang1   

  1. 1 Department of Dermatology and Venerology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; 2 Department of Pathology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
  • Online:2024-04-15 Published:2024-03-26

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摘要： 透明细胞软骨肉瘤是一种生长缓慢、低度恶性的肿瘤，皮肤转移罕见，本文报道1例中年女性患者，左臀部丘疹及全身多发结节伴瘙痒5年余。左臀部丘疹及右臀部结节的组织病理及免疫组化结果均符合转移的透明细胞软骨肉瘤。完善PET-CT提示内脏多发性转移。患者接受化疗联合靶向药物治疗8个疗程后，病情明显好转，目前仍在随访中。

关键词: 透明细胞软骨肉瘤, 皮肤转移, 组织病理, 免疫组化

Abstract: Clear cell chondrosarcoma is a slow-growing and low-grade malignant tumor, its cutaneous metastasis is rare. We report a middle-aged female patient with pruritic papules on the left buttock and multiple nodules on the body for more than five years. Histopathological examination and immunohistochemical staining of the papules and nodule all revealed clear cell chondrosarcoma consistent with metastasis. The PET-CT suggested multiple visceral metastases. The patient achieved striking improvement after eight courses of chemotherapy in combination with targeted agents, the patient was still followed up.

Key words: clear cell chondrosarcoma, cutaneous metastasis, histopathology, immunohistochemistry