中毒性表皮坏死松解症,奥希替尼,表皮生长因子受体," /> 中毒性表皮坏死松解症,奥希替尼,表皮生长因子受体,"/> toxic epidermal necrolysis, osimertinib, epidermal growth factor receptor,"/> 奥希替尼致中毒性表皮坏死松解症一例并文献复习

中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (6): 396-401.doi: 10.12144/zgmfskin202406396

• 论著 • 上一篇    下一篇

奥希替尼致中毒性表皮坏死松解症一例并文献复习

朱莉1,2,赵晴1,2,王娜1,2,冉德林1,2,杨宝琦1,2,刘永霞1,2,刘红1,2,张福仁1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2024-06-15 发布日期:2024-05-07

Toxic epidermal necrolysis caused by osimertinib and literature review

ZHU Li1,2, ZHAO Qing1,2, WANG Na1,2, RAN Delin1,2, YANG Baoqi1,2, LIU Yongxia1,2, LIU Hong1,2, ZHANG Furen1,2   

  1. 1 Hospital for Skin Diseases, Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2024-06-15 Published:2024-05-07

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摘要： 目的：明确一例可能由奥希替尼引起的中毒性表皮坏死松解症的致敏药物。方法：本例中毒性表皮坏死松解症患者发病前曾服用甲磺酸奥希替尼片、枸橼酸莫沙必利片及双氯芬酸钠缓释胶囊，为明确致敏药物采取Naranjo评分、ALDEN评分、淋巴细胞转化试验(lymphocyte transformation test, LTT)以及酶联免疫斑点试验进行验证；对既往报道的相关文献进行检索。结果：经过Naranjo评分、ALDEN评分，奥希替尼均得2分，在所有使用药物中得分最高且奥希替尼的LTT结果为阳性。文献检索中关于服用奥希替尼导致TEN的报道共7例。结论：结合Naranjo评分、ALDEN评分以及LTT的结果，确诊为由奥希替尼引起的中毒性表皮坏死松解症。

关键词: 中毒性表皮坏死松解症')">">中毒性表皮坏死松解症, 奥希替尼, 表皮生长因子受体

Abstract: Objective: To determine the sensitizing drug in a case of toxic epidermal necrolysis (TEN) possibly caused by osimertinib. Methods: The patient with TEN had previously taken osimertinib mesylate tablets, mosapride citrate tablets, and diclofenac sodium sustained-release capsules before the onset of the disease. To identify the sensitizing drug, the Naranjo score, ALDEN score, lymphocyte transformation test (LTT), and Enzyme-Linked Immunospot Assay (Elispot) were performed. Relevant literature was searched and analyzed for further information. Results: The osimertinib were both 2 points of Naranjo score and ALDEN score, which was the highest score among all used drugs, and the LTT result of osimertinib was positive. A total of 7 cases of TEN caused by osimertinib were reported in the literature. Conclusion: Combining the results of Naranjo score, ALDEN score and LTT, the patient was diagnosed with toxic epidermal necrolysis caused by osimertinib.

Key words: toxic epidermal necrolysis')">">toxic epidermal necrolysis, osimertinib, epidermal growth factor receptor