中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (2): 111-113.doi: 10.12144/zgmfskin202602111

• 临床研究 • 上一篇    下一篇

佩索利单抗治疗携带IL36RN基因突变的儿童连续性肢端皮炎一例

吴明明1,2*,孙瑞晗1,2*,王媛1,2,关霄1,2,杜桂营1,2,陈战1,2,肖晶1,2,王建青3   

  1. 1山西省中医院，山西太原，030012；2山西省中医药研究院，山西太原，030012；3山西中医药大学附属医院，山西太原，030024 *共同第一作者
  • 出版日期:2026-02-15 发布日期:2026-01-28

Spesolimab response in a child with acrodermatitis continua of Hallopeau harboring IL36RN gene mutation: a case report

WU Mingming1,2*, SUN Ruihan1,2*, WANG Yuan1,2, GUAN Xiao1,2, DU Guiying1,2, CHEN Zhan1,2, XIAO Jing1,2, WANG Jianqing3   

  1. 1 Shanxi Traditional Chinese Medical Hospital, Taiyuan 030012, China; 2 Shanxi Provincial Institute of Traditional Chinese Medicine, Taiyuan 030012, China; 3 Affiliated Hospital of Shanxi University of Chinese Medicine, Taiyuan 030024, China *Co-first authors
  • Online:2026-02-15 Published:2026-01-28

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摘要： 本文报道佩索利单抗成功治疗连续性肢端皮炎患儿1例。患儿，男，9岁，病史2年余，既往口服中药，局部外用糖皮质激素、抗生素，效果欠佳，患者IL36RN基因检测发现杂合错义突变c.334G＞A和杂合内合子突变c.115+6T＞C。应用佩索利单抗450 mg在第0周和第4周静脉注射,皮损明显缓解，随访1年，皮损消退后未复发，无不良反应。

关键词: 连续性肢端皮炎, 佩索利单抗, IL-36拮抗剂

Abstract: This paper reports a case of successful treatment of acrodermatitis continua of Hallopeau(ACH) in a pediatric patient using spesolimab. The patient,a 9-year-old boy with a disease history of over two years,had previously received oral traditional Chinese medicine, topical corticosteroids, antibiotics preparations with unsatisfactory results. Heterozygous intronic variant (c.115+6T＞C) and heterozygous missense variant (c.334G＞A) were identified in IL36RN gene. After intravenous administration of 450 mg spesolimab at weeks 0 and 4, the skin lesions significantly improved. During the one-year follow-up, the skin lesions resolved without recurrence, and no adverse reactions were observed.

Key words: acrodermatitis continua of Hallopeau, spesolimab, IL-36 inhibitor