中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (11): 816-818.doi: 10.12144/zgmfskin202511816

• 病例报告 • 上一篇    下一篇

佩索利单抗成功治疗妊娠期泛发性脓疱型银屑病一例

吴明明1,2*,王媛1,2*,孙瑞晗1,2,杜桂营1,2,陈战1,2,潘翠翠1,2,王建青1,2   

  1. 1山西省中医院，山西太原，030012；2山西省中医药研究院，山西太原，030012 *共同第一作者
  • 出版日期:2025-11-15 发布日期:2025-11-11

Successful treatment of generalized pustular psoriasis of pregnancy with spesolimab: a case report

WU Mingming1,2*, WANG Yuan1,2*, SUN Ruihan1,2, DU Guiying1,2, CHEN Zhan1,2, PAN Cuicui1,2, WANG Jianqing1,2   

  1. 1 Shanxi Traditional Chinese Medical Hospital, Taiyuan 030012, China; 2 Shanxi Provincial Institute of Traditional Chinese Medicine, Taiyuan 030012, China *Co-first authors
  • Online:2025-11-15 Published:2025-11-11

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摘要： 妊娠期泛发性脓疱型银屑病（generalized pustular psoriasis of pregnancy,GPPP）属于泛发性脓疱型银屑病（generalized pustular psoriasis,GPP）的特殊亚型，以妊娠期全身泛发红斑、脓疱、脱屑，伴高热、寒战等症状为特征，严重者可导致流产或者死亡，目前用于治疗GPP的药物对于孕妇的安全性尚不明确。本文报道佩索利单抗成功治疗GPPP一例。患者，女，31岁，妊娠15周，GPP病史9年，间断发作，1年前曾使用佩索利单抗，症状迅速缓解，妊娠期病情复发，再次使用佩索利单抗900 mg治疗，1周后皮损消退，无不良反应，足月后顺利分娩一名健康婴儿。累计随访1年，患者未复发，婴儿健康。

关键词: 泛发性脓疱型银屑病, 妊娠期, 佩索利单抗, IL-36拮抗剂

Abstract: Generalized pustular psoriasis of pregnancy (GPPP) is a special subtype of generalized pustular psoriasis (GPP), characterized by widespread erythema, pustules, and desquamation during pregnancy, accompanied by high fever, chills, and other symptoms. Severe cases may lead to miscarriage or death. Currently, the safety of medications used to treat GPP in pregnant women remains unclear. We report a case of GPPP successfully treated with spesolimab. The patient, a 31-year-old woman at 15 weeks of gestation, had a 9-year history of GPP with intermittent flare-ups. She had previously received spesolimab one year prior, achieving rapid symptom relief. During pregnancy, her condition recurred, and she was treated again with 900 mg of spesolimab. Within one week, the skin lesions resolved without adverse effects, and she later delivered a healthy baby at full term. After one year of follow-up, the patient remained recurrence-free, and the infant was healthy.

Key words: generalized pustular psoriasis, pregnancy, spesolimab, IL-36 inhibitor