中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (2): 97-100.doi: 10.12144/zgmfskin202602097

• 临床研究 • 上一篇    下一篇

古塞奇尤单抗成功治疗阿达木单抗诱发的泛发性脓疱型银屑病一例并文献复习

白帆,于万龙,魏禹铭,许雅波,雷明君   

  1. 河北中医药大学第一附属医院皮肤一科，河北石家庄,050000
  • 出版日期:2026-02-15 发布日期:2026-01-28

Successful treatment of adalimumab-induced generalized pustular psoriasis with guselkumab: a case report and literature review

BAI Fan, YU Wanlong, WEI Yuming, XU Yabo, LEI Mingjun   

  1. Department of Dermatology, the First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050000, China
  • Online:2026-02-15 Published:2026-01-28

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摘要： 生物制剂已经广泛应用于皮肤病的治疗，但在治疗过程中可能会诱发其他疾病或导致原有疾病加重等不良反应，称为矛盾性反应。本文报道一例斑块状银屑病患者使用阿达木单抗治疗，出现泛发性脓疱型银屑病的矛盾性反应，更换为古塞奇尤单抗治疗。治疗第12周时患者皮损已完全消退，无不良反应发生，目前仍在治疗随访中。

关键词: 古塞奇尤单抗, 阿达木单抗, 泛发性脓疱型银屑病, 矛盾性反应

Abstract: Biological agents have been widely used in the treatment of dematosis，however, they may induce other diseases or exacerbate pre-existing conditions during treatment, a phenomenon known as paradoxical reactions. This case report describes a patient with plaque psoriasis who developed a paradoxical reaction of generalized pustular psoriasis after treatment with adalimumab. The treatment was switched to guselkumab, and complete resolution of skin lesions was achieved at week 12 without adverse reactions. The patient is currently under ongoing treatment and follow-up.

Key words: guselkumab, adalimumab, generalized pustular psoriasis, paradoxical reactions