中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (2): 136-138.doi: 10.12144/zgmfskin202602136

• 综述 • 上一篇    下一篇

新生儿自身免疫性大疱病研究进展

方哲韵,朱海琴,潘萌,王麒钧   

  1. 上海交通大学医学院附属瑞金医院皮肤科,上海,200025
  • 出版日期:2026-02-15 发布日期:2026-01-28

Overview of studies on neonatal autoimmune blistering diseases

FANG Zheyun, ZHU Haiqin, PAN Meng, WANG Qijun   

  1. Department of Dermatology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2026-02-15 Published:2026-01-28

摘要: 新生儿自身免疫性大疱病较为罕见,通常在患儿出生后不久即发生,临床多表现为正常皮肤或黏膜部位出现红斑、水疱、糜烂等病变,该组疾病大多具有自限性,预后良好,部分患儿会遗留不同程度的黏膜损害,出现并发症导致死亡,需要临床医师早期干预、积极治疗。本文综述其发病机制、临床表现、鉴别诊断、治疗及围产期管理等,以期提高临床医师对该病的认识。

关键词: 新生儿自身免疫性大疱病, 寻常型天疱疮, 大疱性类天疱疮, 线状IgA大疱性皮肤病

Abstract: Neonatal autoimmune bullous diseases are relatively rare, usually occurring soon after birth. Clinically, they are mostly characterized by erythema, blisters, erosion and other lesions on normal skin or mucous membranes. Most of these diseases are self-limiting with a good prognosis, while some children may have varying degrees of residual mucosal damage, and a few may die due to complications, which requires early intervention and active treatment by clinicians. This article reviews the pathogenesis, clinical manifestations, differential diagnosis, treatment and perinatal management of these diseases, aiming to improve the understanding of the disease.

Key words: neonatal autoimmune blistering diseases, pemphigus vulgaris, bullous pemphigoid, linear IgA bullous dermatosis