中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (7): 499-504.doi: 10.12144/zgmfskin202607499

• 论著 • 上一篇    下一篇

带状疱疹急性期患者炎症-免疫-营养评分与后遗神经痛疼痛程度的相关性

王磊1,于欢1,余盼2,左小华2   

  1. 1淮安市第二人民医院（徐州医科大学附属淮安医院）麻醉科，江苏淮安，223002；2淮安市第二人民医院（徐州医科大学附属淮安医院）疼痛科，江苏淮安，223002
  • 出版日期:2026-07-15 发布日期:2026-06-29

Correlation between inflammation-immunity-nutrition score and postherpetic neuralgia in patients with acute herpes zoster

WANG Lei1, YU Huan1, YU Pan2, ZUO Xiaohua2   

  1. 1 Department of Anesthesiology, The Second People's Hospital of Huai'an (The Affiliated Huai'an Hospital of Xuzhou Medical University), Huai'an 223002, China; 2 Department of Pain, The Second People's Hospital of Huai'an (The Affiliated Huai'an Hospital of Xuzhou Medical University), Huai'an 223002, China
  • Online:2026-07-15 Published:2026-06-29

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摘要： 目的：初步探究带状疱疹（herpes zoster,HZ）急性期患者炎症-免疫-营养（IINS）评分与后遗神经痛（PHN）疼痛程度的相关性。方法：回顾性收集2022年8月至2025年8月于我院就诊的305例HZ患者的临床资料。根据是否出现PHN分为PHN组（n=82）和非PHN组（n=223）。同期194名健康体检者纳入对照组。采用Spearman相关性分析急性期IINS评分与PHN疼痛严重程度的关系。建立Logistic回归模型并绘制ROC曲线分析IINS评分在PHN风险评估中的应用价值。结果：PHN组患者急性期视觉模拟评分法（VAS）评分、入院时C反应蛋白、发病至治疗时间＞3天、坏疽型/出血型的人数占比均显著高于非PHN组，淋巴细胞、白蛋白水平低于非PHN组和对照组（均P＜0.05）。PHN组患者IINS评分高于非PHN组和对照组（P＜0.05）。PHN患者IINS评分和疼痛等级指数、现有疼痛强度、VAS评分呈中度正相关（P＜0.05）。IINS评分升高（OR：7.262）是PHN发生的独立危险因素（均P＜0.05）。IINS评分预测PHN发生的AUC为0.845，预测效能优于S100β蛋白、神经元特异性烯醇化酶（均P＜0.05）。三者联合检测AUC达0.934。结论：IINS评分与PHN患者的疼痛程度呈中度正相关，可作为 PHN 早期风险评估的有效指标，联合S100β、NSE检测能进一步提高预测准确性，为临床早期干预提供依据。

关键词: 带状疱疹, 炎症-免疫-营养评分, 后遗神经痛, 疼痛程度

Abstract: Objective: To preliminarily investigate the correlation between the inflammation-immunity-nutrition score (IINS) and the severity of postherpetic neuralgia (PHN) in patients with acute herpes zoster (HZ). Methods: Clinical data were retrospectively collected from 305 HZ patients treated in our hospital between August 2022 and August 2025. Patients were divided into a PHN group (n = 82) and a non-PHN group (n = 223) based on the occurrence of PHN. A control group of 194 healthy individuals undergoing routine physical examinations during the same period was included. Spearman correlation analysis was conducted to assess the relationship between acute-phase IINS and PHN severity. A logistic regression model was developed, and ROC curves were plotted to analyze the value of the IINS in assessing the risk of PHN. Results: Patients in the PHN group demonstrated significantly higher acute-phase visual analog scale (VAS) scores, higher C-reactive protein levels at admission, a higher proportion of cases with onset-to-treatment time ＞ 3 days, and a higher proportion of gangrenous/hemorrhagic HZ compared to the non-PHN group. Lymphocyte and albumin levels were lower in the PHN group than in the non-PHN group and the control group (all P＜ 0.05). PHN patients exhibited higher IINS than the non-PHN group and the control group (P＜0.05). In PHN patients, IINS had moderate positive correlations with pain index, pain intensity, and VAS scores (P＜0.05). Elevated IINS (OR: 7.262) constituted an independent risk factor for PHN (all P＜0.05). The AUC of IINS for predicting PHN was 0.845, demonstrating significantly superior predictive performance compared to S100β and neuron-specific enolase (all P＜0.05). The combined assay of the three parameters yielded an AUC of 0.934. Conclusion: The IINS score is moderately positively correlated with pain severity in PHN patients and can serve as an effective indicator for early risk assessment of PHN. Combined detection with S100β and NSE can further improve predictive accuracy, providing a basis for early clinical intervention.

Key words: herpes zoster, inflammation-immunity-nutrition score, postherpetic neuralgia, pain severity