中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (8): 599-601.doi: 10.12144/zgmfskin202608599

• 病例报告 • 上一篇    下一篇

度普利尤单抗治疗特应性皮炎合并20甲营养不良一例

蒲芊涵1,郑晨2,邹爱玲1,2   

  1. 1 武汉科技大学医学部黄石市中心医院研究生培养基地皮肤科，湖北黄石，435000；2黄石市中心医院（湖北理工学院附属医院），湖北黄石，435000
  • 出版日期:2026-08-15 发布日期:2026-08-03

Dupilumab for the treatment of atopic dermatitis complicated with twenty-nail dystrophy: a case report

PU Qianhan1, ZHENG Chen2, ZOU Ailing1,2   

  1. 1 Department of Dermatology, Huangshi Central Hospital Graduate Joint Training Base, Wuhan University of Science and Technology, Huangshi 435000, China; 2 Huangshi Central Hospital (Affiliated Hospital of Hubei University of Technology), Huangshi 435000, China
  • Online:2026-08-15 Published:2026-08-03

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摘要： 本文报道度普利尤单抗成功治疗儿童特应性皮炎合并20甲营养不良一例。患儿，女，8岁，手足20指/趾甲出现增厚、浑浊、畸形伴甲板粗糙不平，甲损害逐渐加重但无自觉症状2年，曾口服抗真菌治疗疗效不佳。追溯病史，患儿在甲损害发生之前出现全身干燥瘙痒，根据病史、临床表现及实验室检查，诊断为特应性皮炎合并20甲营养不良。治疗方案采用以度普利尤单抗首次剂量600 mg皮下注射，随后依疗程阶梯式递减剂量。治疗期间，患儿全身皮肤干燥瘙痒得到有效缓解，且指/趾甲恢复良好，停药半年未复发。

关键词: 20甲营养不良, 度普利尤单抗, 特应性皮炎

Abstract: This paper reports a case of dupilumab treatment for childhood atopic dermatitis predominantly manifested as twenty-nail dystrophy. The patient was an 8-year-old girl who presented with thickening, opacification, deformity and rough nail plates of all twenty fingernails and toenails. The nail lesions had progressively worsened over 2 years without subjective symptoms, and previous oral antifungal therapy yielded no satisfactory response. Medical history review revealed generalized xerosis and pruritus prior to the onset of nail lesions. Combined with clinical manifestations and laboratory examinations, the patient was diagnosed with atopic dermatitis complicated by twenty-nail dystrophy. The patient received subcutaneous injection of dupilumab at an initial dose of 600 mg, followed by dose tapering as scheduled. During the treatment period, the patient's generalized cutaneous xerosis and pruritus were effectively alleviated, and the fingernails and toenails recovered well, and no recurrence was observed during the 6-month follow-up after drug discontinuation.

Key words: twenty-nail dystrophy, dupilumab, atopic dermatitis