中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (4): 263-266.doi: 10.12144/zgmfskin202404263

• 临床研究 • 上一篇    下一篇

艾滋病合并猴痘临床病理分析

常静1,张玉姣2,周光德1   

  1. 1首都医科大学附属北京佑安医院病理科，北京，100069；2中日友好医院感染疾病科，北京，100029
  • 出版日期:2024-04-15 发布日期:2024-03-26

Clinical and pathological analysis of monkeypox in AIDS patients

CHANG Jing1, ZHANG Yujiao2, ZHOU Guangde1   

  1. 1 Department of Pathology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China; 2 Department of Infectious Department, China-Japan Friendship Hospital, Beijing 100029, China
  • Online:2024-04-15 Published:2024-03-26

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摘要： 本文分析了近期确诊的3例艾滋病合并猴痘患者临床表现和皮损组织学特征。3例患者均为青年男性，生殖器周围皮疹为首发表现，后扩散至全身，2例伴发热、1例有腹股沟淋巴结肿大，外周血HIV抗体阳性。咽拭子、皮疹拭子及肛拭子等标本猴痘病毒PCR检测均阳性；活检皮肤病理组织学表现一致：局部表皮全层及真皮浅层碎屑状坏死，坏死周围表皮细胞水肿及气球样变、多量中性粒细胞浸润伴核尘，表皮细胞胞质见嗜酸性小体，真皮层多量淋巴细胞、中性及嗜酸性粒细胞浸润。

关键词: 猴痘, 艾滋病, 皮肤病理

Abstract: We analyzed the clinical manifestations and histological characteristics of skin lesions in 3 recently confirmed AIDS patients with monkeypox. All the 3 patients were young men, and there were initial genital rash spread throughout the body, 2 patients with fever, 1 patient with an inguinal lymph node enlargement. The peripheral blood HIV antibody was positive . Pharyngeal swabs, rash swabs and anal swabs and other specimens were positive for monkeypox virus PCR test. The biopsy characteristics were consistent, which revealed piece-meal necrosis in local epidermal whole layer and superficial dermis, and the cells surrounding necrosis were odema and balloon changes, with many neutrophile granulocyte and nuclear dust. There were many infiltration of lymphocytes, neutrophile granulocyte and eosinophils in the dermis.

Key words: monkeypox, AIDS, skin pathology