中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (7): 519-523.doi: 10.12144/zgmfskin202407519

• 综述 • 上一篇    下一篇

JAK抑制剂在白癜风治疗中的应用进展

衍元元1,赵艳霞2,成玉3   

  1. 1天津中医药大学，天津，301617；2天津市中医药研究院附属医院，天津，300120；3首都医科大学附属北京中医医院，北京，100010
  • 出版日期:2024-07-15 发布日期:2024-06-12

Update of Janus kinase inhibitors in the treatment of vitiligo

YAN Yuanyuan1, ZHAO Yanxia2, CHENG Yu3   

  1. 1 Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; 2 Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin 300120, China; 3 Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
  • Online:2024-07-15 Published:2024-06-12

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摘要： 近年来，较多研究表明Janus激酶-信号转导和转录激活因子(JAK-STAT)信号通路在白癜风免疫发病机制中起着重要作用，而基于此通路的Janus激酶(JAK)抑制剂，在白癜风治疗中显示出强大的治疗前景。文章对近几年JAK抑制剂在白癜风中的作用机制、临床疗效和安全性等方面的研究进展进行了综述。

关键词: 白癜风, JAK-STAT信号通路, JAK抑制剂

Abstract: In recent years, more studies have shown that JAK-STAT signaling pathway plays an important role in the immune pathogenesis of vitiligo, and JAK inhibitors based on this pathway have shown a strong therapeutic prospect in the treatment of vitiligo. The update of the mechanism, clinical efficacy and safety of JAK inhibitors of vitiligo in recent years are reviewed in this paper.

Key words: vitiligo, JAK-STAT signaling pathway, JAK inhibitors