中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (10): 765-770.doi: 10.12144/zgmfskin202510765

• 综述 • 上一篇    

特应性皮炎瘙痒机制研究进展

孙静怡,高明萱,姚新宇,周灵萱,赵嘉惠   

  1. 北京大学第一医院皮肤性病科,国家皮肤与免疫疾病临床医学研究中心,皮肤病分子诊断北京市重点实验室,国家药品监督管理局化妆品质量控制与评价重点实验室，北京,100034
  • 出版日期:2025-10-15 发布日期:2025-09-29

Advances in understanding the pruritic mechanisms of atopic dermatitis

SUN Jingyi, GAO Mingxuan, YAO Xinyu, ZHOU Lingxuan, ZHAO Jiahui   

  1. Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, National Clinical Research Center for Skin and Immune Disease, NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics, Beijing 100034, China
  • Online:2025-10-15 Published:2025-09-29

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摘要： 特应性皮炎是一种慢性炎症性皮肤病，以剧烈瘙痒和反复发作为特征。瘙痒被认为是特应性皮炎的一个核心表现，其机制尤为复杂。近年来研究表明，神经免疫交互作用、皮肤屏障功能障碍在特应性皮炎瘙痒中起关键作用。本文综述了瘙痒相关机制及治疗进展。

关键词: 特应性皮炎, 瘙痒, 神经免疫, 皮肤屏障

Abstract: Atopic dermatitis is a chronic inflammatory skin disease characterized by intense pruritus and recurrent episodes. Pruritus is regarded as a core manifestation of atopic dermatitis, with an especially complex underlying mechanism. Recent studies have indicated that neuroimmune interactions and skin barrier dysfunction play key roles in atopic dermatitis-related pruritus. This paper reviews the the pruritus-related mechanisms and advances in therapeutic approaches.

Key words: atopic dermatitis, pruritus, neuroimmunity, skin barrier