Abstract: A 77-year-old male presented with bilateral scrotal swelling. He had an operation on the left renal pelvis carcinoma two months ago. Pathological examination showed urothelial carcinoma. After the bladder perfusion with gemcitabine, bilateral scrotal swelling occurred with redness and ulceration of the epidermis. The burning pain was obvious. The diagnosis of contact dermatitis caused by extravasation of chemotherapy drugs was made. The problem wasl improved after conservative treatment.

Key words: antineoplastic drugs, scrotum, cutaneous necrosis, gemcitabine