Abstract: A 25-year-old female with acquired bullous epidermolysis (EBA) was reported and related literature was reviewed. The patient presented with tense blisters, negative Nikolsky's sign and once was  misdiagnosed as pemphigus, linear IgA bullous dermatosis in other hospitals. Biopsy showed blaster in subepidermal. Salt-split skin indirect immunofluorescence showed IgG deposition in dermis and indirect immunofluorescence showed basement film belt deposition of IgG, C3, IgM and IgA. Elisa showed negative BP180 and BP230. The diagnosis of EBA was made. The patient was treated with methylprednisolone, dapsone, human immunoglobulin, mycophenol ester and the condition improved.

Key words: bullous epidermolysis, acquired, repeated misdiagnosis