Abstract: Atopic dermatitis is a chronic relapsing inflammatory skin disease that involves a variety of immune cells. The langerhans cell plays an important role in starting and maintaining the disease. The migration of langerhans cell to the skin lymph nodes happens at the early stage of the dermatitis, and then, it gets activated and leads to Th2 type immunoreaction. In terms of treatment, betamethasone and macrolide antibiotics can inhibit langerhans cell-induced Th2-type inflammation. Tar and histamine 4 receptor antagonists can inhibit the expression of CCL17 and CCL22 by langerhans cell. The update of the role of langerhans cell in the immune mechanism and treatment in atopic dermatitis is reviewed in this paper.

Key words: atopic dermatitis, langerhans cells, immune response, filaggrin