Abstract: Transient receptor potential (TRP) channel is a family of nonspecific cationic channel proteins, which are widely expressed in sensory neurons and non-neuronal cells of skin. TRP channels can be activated by a variety of stimuli, thus participating in the occurrence and development of inflammatory skin diseases. This review focuses on the role of different TRP channel subtypes in inflammatory skin diseases such as rosacea, atopic dermatitis, psoriasis and contact dermatitis, suggesting that TRP channels may be potential therapeutic targets for inflammatory skin diseases.

Key words: transient receptor potential channel, inflammatory skin disease, rosacea, psoriasis, atopic dermatitis