China Journal of Leprosy and Skin Diseases ›› 2022, Vol. 38 ›› Issue (7): 488-492.doi: 10.12144/zgmfskin202207488

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Update of mesenchymal stem cells in the treatment of psoriasis

ZHAO Ziwei1, LI Junqin2, NIU Xuping2, HOU Ruixia2, YANG Yanni3, LI Xinhua2   

  1. 1 School of Public Health, Shanxi Medical University, Taiyuan 030001, China; 2 Department of Dermatology,Taiyuan Key Laboratory of Stem Cell for Immunological Dermatosis, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan 030009, China; 3 Hospital Management Office of Shanxi Medical University, Taiyuan 030600, China
  • Online:2022-07-15 Published:2022-05-17

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Abstract: Mesenchymal stem cells (MSCs) are pluripotent adult stem cells with the potential for self-renewal, multi-lineage differentiation and immunomodulatory properties. Studies have reported the presence of MSCs in the dermis and epidermis of patients with psoriasis and suggested that MSCs may promote the inflammatory process and psoriatic lesions development through high HLA-Ⅰexpression and low immunosuppressive capacity against CD3+T cells. At present, the safety and efficacy of MSCs infusion have been confirmed in mice psoriasis models induced by imiquimod and clinical trials, but there may be potential risks. The update of MSCs in the treatment of psoriasis is reviewed in this paper.

Key words: psoriasis, mesenchymal stem cells, immune intervention, cellular therapy