Abstract: A 61-year-old male presented with brownish reticulate pigmentation with hypopigmented and hyperpigmented macules all over the body for more than ten years. His father and elder brother share the same skin characteristics. The skin biopsy of the lesion showed epidermal hyperkeratosis and acanthosis, accompanied by perivascular lymphocytic infiltration in the superficial dermis. Eosinophilic clumps can be found in the dermal papilla. Additionally, Congo red stain in dermal papilla was positive. The diagnosis of amyloidosis cutis dyschromica was made according to the clinical manifestation and laboratory results.

Key words: amyloidosis cutis dyschromica, primary cutaneous amyloidosis