Abstract: A case of generalized annular granuloma in an elder successfully treated with adalimumab was reported and relevant literature was reviewed. A 76-year-old man presented with generalized annular plaques on the trunk and extremities. Histopathological examination showed mild hyperplasia of epidermis, epithelioid granuloma in the dermis, degeneration and necrosis of central collagen fibers, infiltration of tissue cells and lymphocytes around granuloma, hyperplasia of collagen fibers, and scattered infiltration of mononuclear cells among collagen fibers. The diagnoses of generalized annular granuloma was made. The patient was treated with adalimumab injection 80mg firstly, then was given 40mg at week 1, 3, 5, 7, 9 after first treatment. The lesions subsided, leaving a small amount of pigmentation after 3-month treatment. 

Key words: generalized granuloma annulare, adalimumab