单纯型大疱性表皮松解症治疗研究进展

doi:10.12144/zgmfskin202210741

China Journal of Leprosy and Skin Diseases ›› 2022, Vol. 38 ›› Issue (10): 741-746.doi: 10.12144/zgmfskin202210741

• Reviews • Previous Articles Next Articles

Research progress in treatment of epidermolysis bullosa simplex

WANG Hua¹, TANG Jiajian², SHEN Ling¹, SONG Yan¹

1 Guangzhou Link Health Pharma Co. Ltd, Guangzhou 510663,China;2 School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084,China

Online:2022-10-15 Published:2022-08-23

Abstract

Abstract: Epidermolysis bullosa simplex is a rare genodermatosis. The current treatment focused on symptom-relieved therapies, including anti-inflammation, antipruritic and antiperspirant, and other treatments including mesenchymal stem cell, implantation of pluripotent stem cells and transcription activator-like effector nuclease, CRISPER/Cas9. The update of the treatments of epidermolysis bullosa is reviewed in this paper.

Key words: epidermolysis bullosa simplex, genodermatosis, keratin, Oleogel-S10, Diacerein

WANG Hua, TANG Jiajian, SHEN Ling, SONG Yan. Research progress in treatment of epidermolysis bullosa simplex[J].China Journal of Leprosy and Skin Diseases, 2022, 38(10): 741-746.

[1]	YANG Beibei, WU Weimin, XIAO Hua. A novel mutation of keratin 5 in epidermolysis bullosa simplex with migratory circinate erythema in a Chinese family [J]. China Journal of Leprosy and Skin Diseases, 2022, 38(9): 604-606.
[2]	LI Jinzhuo, LIN Zhipeng, ZENG Qianwen, SUN Renshan. Update on the effect of PM2.5 on skin keratinocytes [J]. China Journal of Leprosy and Skin Diseases, 2021, 37(8): 537-542.
[3]	SUN Jie, WANG Rui, HUANG Min, BAI Jia, LI Chengxin. Effect of IL-17A on insulin resistance in keratinocytes [J]. China Journal of Leprosy and Skin Diseases, 2021, 37(5): 271-275.
[4]	ZHANG Qi, WANG Zaixing, YANG Sen. Progress of keratin in skin aging [J]. China Journal of Leprosy and Skin Diseases, 2021, 37(2): 113-115.
[5]	HAN Yue, YAO Xu. Activation and inflammation of HaCaT Cells regulated by exosomes in peripheral blood of the patients with atopic dermatitis [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(2): 70-74.
[6]	ZHU Jianwei, LUO Dan. Down-regulation of IFN-γ-induced over-expression of surface antigens on normal human keratinocytes by UVB [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(1): 16-19.
[7]	REN Kaixuan, XIA Yumin. Effect of cold atmospheric plasma exhibits biological on cutaneous keratinocytes [J]. China Journal of Leprosy and Skin Diseases, 2019, 35(7): 441-444.
[8]	LI Yuanyuan, SHE Huihui, QIAN Longbao, WEI Shicai. Effect of keratinocyte and fibroblast on the pathogenesis and treatment of vitiligo [J]. China Journal of Leprosy and Skin Diseases, 2019, 35(11): 701-704.
[9]	YAO Qiyu, LUO Yang, YAO Xu, LIU Jun. Effect of linoleic acid on the expression of keratinocytes barrier-associated protein [J]. China Journal of Leprosy and Skin Diseases, 2019, 35(10): 584-586.
[10]	HUANG Dan, JU Mei, CHEN Kun, WU Minzhi, GU Heng. Effect of α-lipoic acid on oxidative stress of keratinocytes induced by UVB [J]. China Journal of Leprosy and Skin Diseases, 2019, 35(1): 1-5.
[11]	WU Yuanyuan, ZHENG Jie, XIAO Fengli. Keratinocytes and atopic dermatitis [J]. China Journal of Leprosy and Skin Diseases, 2019, 35(1): 54-56.
[12]	ZHU Shanshan, Wang Yunlong, PANG Chuanchao. Expression of IL-22 in the lesions of lichen planus [J]. China Journal of Leprosy and Skin Diseases, 2018, 34(7): 418-421.
[13]	SUN Yaqi, SU Ting, CHEN Yiwen, ZHANG Meihua, SU Zhonglan. Norwegian scabies in a patient with epidermolysis bullosa simplex and lupus nephritis [J]. China Journal of Leprosy and Skin Diseases, 2018, 34(11): 680-682.
[14]	CHEN Fuying, LI Ming.. Update of the abnormal cholesterol metabolism and keratinization genodermatosis [J]. China Journal of Leprosy and Skin Diseases, 2017, 33(8): 506-509.
[15]	CHEN Pingjiao, LI Changxing, ZENG Kang, ZHANG Xibao.. Update of the genetics of bullous congenital ichthyosiform erythroderma [J]. China Journal of Leprosy and Skin Diseases, 2017, 33(6): 381-384.

Research progress in treatment of epidermolysis bullosa simplex

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 10