Abstract: Objective: To investigate the bacterial agents distribution and drug-resistance pattern in inpatients of skin and soft tissue infections(SSTI). Methods: A total of 571 SSTI patients with positive germiculture results were selected from our hospital from January 1, 2018 to December 31, 2020. Analyze the distribution characteristics of pathogenic bacteria in different diseases and drug resistance of dominant Gram-positive bacteria. Results: According to disease classification, there were pemphigus, bullous pemphigus, eczema, psoriasis, etc. A total of 624 strains were cultured in 571 SSTI patients, including 529 Gram-positive strains (84.8%), 76 Gram-negative strains (12.1%) and 19 fungal strains (3.0%). The main dominant bacteria were Staphylococcus aureus, Staphylococcus haemolyticus and Staphylococcus intermediatus, which were significantly resistant to penicillin, erythromycin and azithromycin, and the sensitivity to minocycline and teicoranin were 100%. Conclusion: Staphylococcus aureus was the most important pathogen in SSTI, Gram-positive dominant bacteria had high drug resistance rate to penicillin, azithromycin and erythromycin, and high sensitivity to minocycline, doxycycline, teicoranin and linezolid, which could guide clinical medication.

Key words: skin and soft tissue infections, germiculture, drug sensitive test, drug resistance